Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Acquired resistance to chemotherapy can lead to multi-drug resistance and poor prognosis in cancer. Here, the authors show that Rac1 increases glycolysis and non-oxidative pentose phosphate pathway activity leading to neoadjuvant chemotherapy (NAC) resistance, thus its inhibition sensitizes resistan...

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Autores principales: Qingjian Li, Tao Qin, Zhuofei Bi, Huangming Hong, Lin Ding, Jiewen Chen, Wei Wu, Xiaorong Lin, Wenkui Fu, Fang Zheng, Yandan Yao, Man-Li Luo, Phei Er Saw, Gerburg M. Wulf, Xiaoding Xu, Erwei Song, Herui Yao, Hai Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/efec27f7cd8e413ab798c30a495d8ab0
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Sumario:Acquired resistance to chemotherapy can lead to multi-drug resistance and poor prognosis in cancer. Here, the authors show that Rac1 increases glycolysis and non-oxidative pentose phosphate pathway activity leading to neoadjuvant chemotherapy (NAC) resistance, thus its inhibition sensitizes resistant breast cancer PDXs to NAC.

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