Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Acquired resistance to chemotherapy can lead to multi-drug resistance and poor prognosis in cancer. Here, the authors show that Rac1 increases glycolysis and non-oxidative pentose phosphate pathway activity leading to neoadjuvant chemotherapy (NAC) resistance, thus its inhibition sensitizes resistan...

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Autores principales:	Qingjian Li, Tao Qin, Zhuofei Bi, Huangming Hong, Lin Ding, Jiewen Chen, Wei Wu, Xiaorong Lin, Wenkui Fu, Fang Zheng, Yandan Yao, Man-Li Luo, Phei Er Saw, Gerburg M. Wulf, Xiaoding Xu, Erwei Song, Herui Yao, Hai Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/efec27f7cd8e413ab798c30a495d8ab0
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spelling	oai:doaj.org-article:efec27f7cd8e413ab798c30a495d8ab02021-12-02T15:39:11ZRac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer10.1038/s41467-020-15308-72041-1723https://doaj.org/article/efec27f7cd8e413ab798c30a495d8ab02020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15308-7https://doaj.org/toc/2041-1723Acquired resistance to chemotherapy can lead to multi-drug resistance and poor prognosis in cancer. Here, the authors show that Rac1 increases glycolysis and non-oxidative pentose phosphate pathway activity leading to neoadjuvant chemotherapy (NAC) resistance, thus its inhibition sensitizes resistant breast cancer PDXs to NAC.Qingjian LiTao QinZhuofei BiHuangming HongLin DingJiewen ChenWei WuXiaorong LinWenkui FuFang ZhengYandan YaoMan-Li LuoPhei Er SawGerburg M. WulfXiaoding XuErwei SongHerui YaoHai HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingjian Li Tao Qin Zhuofei Bi Huangming Hong Lin Ding Jiewen Chen Wei Wu Xiaorong Lin Wenkui Fu Fang Zheng Yandan Yao Man-Li Luo Phei Er Saw Gerburg M. Wulf Xiaoding Xu Erwei Song Herui Yao Hai Hu Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
description	Acquired resistance to chemotherapy can lead to multi-drug resistance and poor prognosis in cancer. Here, the authors show that Rac1 increases glycolysis and non-oxidative pentose phosphate pathway activity leading to neoadjuvant chemotherapy (NAC) resistance, thus its inhibition sensitizes resistant breast cancer PDXs to NAC.
format	article
author	Qingjian Li Tao Qin Zhuofei Bi Huangming Hong Lin Ding Jiewen Chen Wei Wu Xiaorong Lin Wenkui Fu Fang Zheng Yandan Yao Man-Li Luo Phei Er Saw Gerburg M. Wulf Xiaoding Xu Erwei Song Herui Yao Hai Hu
author_facet	Qingjian Li Tao Qin Zhuofei Bi Huangming Hong Lin Ding Jiewen Chen Wei Wu Xiaorong Lin Wenkui Fu Fang Zheng Yandan Yao Man-Li Luo Phei Er Saw Gerburg M. Wulf Xiaoding Xu Erwei Song Herui Yao Hai Hu
author_sort	Qingjian Li
title	Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
title_short	Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
title_full	Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
title_fullStr	Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
title_full_unstemmed	Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
title_sort	rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/efec27f7cd8e413ab798c30a495d8ab0
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Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

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