Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment

Metabolism differs significantly between tumor and normal cells. Metabolic reprogramming in cancer cells and metabolic interplay in the tumor microenvironment (TME) are important for tumor formation and progression. Tumor cells show changes in both catabolism and anabolism. Altered aerobic glycolysi...

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Autores principales:	Lisha Bao, Tong Xu, Xixuan Lu, Ping Huang, Zongfu Pan, Minghua Ge
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	metabolic reprogramming thyroid cancer microenvironment metabolic interplay Warburg effect Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/eff1a2e6e92044e887ea7f83a3fda94b
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spelling	oai:doaj.org-article:eff1a2e6e92044e887ea7f83a3fda94b2021-12-02T08:28:11ZMetabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment2234-943X10.3389/fonc.2021.773028https://doaj.org/article/eff1a2e6e92044e887ea7f83a3fda94b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.773028/fullhttps://doaj.org/toc/2234-943XMetabolism differs significantly between tumor and normal cells. Metabolic reprogramming in cancer cells and metabolic interplay in the tumor microenvironment (TME) are important for tumor formation and progression. Tumor cells show changes in both catabolism and anabolism. Altered aerobic glycolysis, known as the Warburg effect, is a well-recognized characteristic of tumor cell energy metabolism. Compared with normal cells, tumor cells consume more glucose and glutamine. The enhanced anabolism in tumor cells includes de novo lipid synthesis as well as protein and nucleic acid synthesis. Although these forms of energy supply are uneconomical, they are required for the functioning of cancer cells, including those in thyroid cancer (TC). Increasing attention has recently focused on alterations of the TME. Understanding the metabolic changes governing the intricate relationship between TC cells and the TME may provide novel ideas for the treatment of TC.Lisha BaoLisha BaoLisha BaoTong XuXixuan LuXixuan LuPing HuangPing HuangZongfu PanZongfu PanMinghua GeMinghua GeFrontiers Media S.A.articlemetabolic reprogrammingthyroid cancermicroenvironmentmetabolic interplayWarburg effectNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic reprogramming thyroid cancer microenvironment metabolic interplay Warburg effect Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	metabolic reprogramming thyroid cancer microenvironment metabolic interplay Warburg effect Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lisha Bao Lisha Bao Lisha Bao Tong Xu Xixuan Lu Xixuan Lu Ping Huang Ping Huang Zongfu Pan Zongfu Pan Minghua Ge Minghua Ge Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment
description	Metabolism differs significantly between tumor and normal cells. Metabolic reprogramming in cancer cells and metabolic interplay in the tumor microenvironment (TME) are important for tumor formation and progression. Tumor cells show changes in both catabolism and anabolism. Altered aerobic glycolysis, known as the Warburg effect, is a well-recognized characteristic of tumor cell energy metabolism. Compared with normal cells, tumor cells consume more glucose and glutamine. The enhanced anabolism in tumor cells includes de novo lipid synthesis as well as protein and nucleic acid synthesis. Although these forms of energy supply are uneconomical, they are required for the functioning of cancer cells, including those in thyroid cancer (TC). Increasing attention has recently focused on alterations of the TME. Understanding the metabolic changes governing the intricate relationship between TC cells and the TME may provide novel ideas for the treatment of TC.
format	article
author	Lisha Bao Lisha Bao Lisha Bao Tong Xu Xixuan Lu Xixuan Lu Ping Huang Ping Huang Zongfu Pan Zongfu Pan Minghua Ge Minghua Ge
author_facet	Lisha Bao Lisha Bao Lisha Bao Tong Xu Xixuan Lu Xixuan Lu Ping Huang Ping Huang Zongfu Pan Zongfu Pan Minghua Ge Minghua Ge
author_sort	Lisha Bao
title	Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment
title_short	Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment
title_full	Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment
title_fullStr	Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment
title_full_unstemmed	Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment
title_sort	metabolic reprogramming of thyroid cancer cells and crosstalk in their microenvironment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/eff1a2e6e92044e887ea7f83a3fda94b
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Metabolic Reprogramming of Thyroid Cancer Cells and Crosstalk in Their Microenvironment

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