Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner.

Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner.

<h4>Background</h4>Parkinson's disease is characterized by the presence of cytoplasmic inclusions, known as Lewy bodies, containing both aggregated α-synuclein and its interaction partner, synphilin-1. While synphilin-1 is known to accelerate inclusion formation by α-synuclein in ma...

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Autores principales: Sabrina Büttner, Charlotte Delay, Vanessa Franssens, Tine Bammens, Doris Ruli, Sandra Zaunschirm, Rita Machado de Oliveira, Tiago Fleming Outeiro, Frank Madeo, Luc Buée, Marie-Christine Galas, Joris Winderickx
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/eff3ee3d67ce4869b535f6da06364db5
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