The Role of Chemokines in Cervical Cancers

Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. T...

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Autores principales:	Fabian Garrido, Carl Mathis Wild, Johanna Mittelberger, Franziska Dobler, Mariella Schneider, Nadine Ansorge, Melitta Köpke, Annamarie Strieder, Nina Ditsch, Udo Jeschke, Christian Dannecker
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CCL1-28 CXCL1-17 XCL1-2 CX3CL1 immune checkpoints PD-1 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eff9430cfcc14ffaa5d6f1a4a352b121
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spelling	oai:doaj.org-article:eff9430cfcc14ffaa5d6f1a4a352b1212021-11-25T18:18:00ZThe Role of Chemokines in Cervical Cancers10.3390/medicina571111411648-91441010-660Xhttps://doaj.org/article/eff9430cfcc14ffaa5d6f1a4a352b1212021-10-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1141https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. Therefore, a clear understanding of chemokines and immune checkpoint modulators is essential for the treatment of this disease. This review discusses the origins and categories of chemokines and the mechanisms that are responsible for activating immune checkpoints in cervical dysplasia and cancer, chemokines as biomarkers, and therapy development that targets immune checkpoints in cervical cancer research.Fabian GarridoCarl Mathis WildJohanna MittelbergerFranziska DoblerMariella SchneiderNadine AnsorgeMelitta KöpkeAnnamarie StriederNina DitschUdo JeschkeChristian DanneckerMDPI AGarticleCCL1-28CXCL1-17XCL1-2CX3CL1immune checkpointsPD-1Medicine (General)R5-920ENMedicina, Vol 57, Iss 1141, p 1141 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CCL1-28 CXCL1-17 XCL1-2 CX3CL1 immune checkpoints PD-1 Medicine (General) R5-920
spellingShingle	CCL1-28 CXCL1-17 XCL1-2 CX3CL1 immune checkpoints PD-1 Medicine (General) R5-920 Fabian Garrido Carl Mathis Wild Johanna Mittelberger Franziska Dobler Mariella Schneider Nadine Ansorge Melitta Köpke Annamarie Strieder Nina Ditsch Udo Jeschke Christian Dannecker The Role of Chemokines in Cervical Cancers
description	Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. Therefore, a clear understanding of chemokines and immune checkpoint modulators is essential for the treatment of this disease. This review discusses the origins and categories of chemokines and the mechanisms that are responsible for activating immune checkpoints in cervical dysplasia and cancer, chemokines as biomarkers, and therapy development that targets immune checkpoints in cervical cancer research.
format	article
author	Fabian Garrido Carl Mathis Wild Johanna Mittelberger Franziska Dobler Mariella Schneider Nadine Ansorge Melitta Köpke Annamarie Strieder Nina Ditsch Udo Jeschke Christian Dannecker
author_facet	Fabian Garrido Carl Mathis Wild Johanna Mittelberger Franziska Dobler Mariella Schneider Nadine Ansorge Melitta Köpke Annamarie Strieder Nina Ditsch Udo Jeschke Christian Dannecker
author_sort	Fabian Garrido
title	The Role of Chemokines in Cervical Cancers
title_short	The Role of Chemokines in Cervical Cancers
title_full	The Role of Chemokines in Cervical Cancers
title_fullStr	The Role of Chemokines in Cervical Cancers
title_full_unstemmed	The Role of Chemokines in Cervical Cancers
title_sort	role of chemokines in cervical cancers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/eff9430cfcc14ffaa5d6f1a4a352b121
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The Role of Chemokines in Cervical Cancers

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