Chiral DNA sequences as commutable controls for clinical genomics

Any DNA sequence can be represented by a chiral partner sequence – an exact copy arranged in reverse nucleotide order. Here, the authors show that chiral DNA sequence pairs share important properties and show the utility of synthetic chiral sequences (sequins) as controls for clinical genomics.

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Autores principales:	Ira W. Deveson, Bindu Swapna Madala, James Blackburn, Chris Barker, Ted Wong, Kirston M. Barton, Martin A. Smith, D. Neil Watkins, Tim R. Mercer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eff97fe0e26c48849a3f468dba362eb7
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spelling	oai:doaj.org-article:eff97fe0e26c48849a3f468dba362eb72021-12-02T14:39:18ZChiral DNA sequences as commutable controls for clinical genomics10.1038/s41467-019-09272-02041-1723https://doaj.org/article/eff97fe0e26c48849a3f468dba362eb72019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09272-0https://doaj.org/toc/2041-1723Any DNA sequence can be represented by a chiral partner sequence – an exact copy arranged in reverse nucleotide order. Here, the authors show that chiral DNA sequence pairs share important properties and show the utility of synthetic chiral sequences (sequins) as controls for clinical genomics.Ira W. DevesonBindu Swapna MadalaJames BlackburnChris BarkerTed WongKirston M. BartonMartin A. SmithD. Neil WatkinsTim R. MercerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ira W. Deveson Bindu Swapna Madala James Blackburn Chris Barker Ted Wong Kirston M. Barton Martin A. Smith D. Neil Watkins Tim R. Mercer Chiral DNA sequences as commutable controls for clinical genomics
description	Any DNA sequence can be represented by a chiral partner sequence – an exact copy arranged in reverse nucleotide order. Here, the authors show that chiral DNA sequence pairs share important properties and show the utility of synthetic chiral sequences (sequins) as controls for clinical genomics.
format	article
author	Ira W. Deveson Bindu Swapna Madala James Blackburn Chris Barker Ted Wong Kirston M. Barton Martin A. Smith D. Neil Watkins Tim R. Mercer
author_facet	Ira W. Deveson Bindu Swapna Madala James Blackburn Chris Barker Ted Wong Kirston M. Barton Martin A. Smith D. Neil Watkins Tim R. Mercer
author_sort	Ira W. Deveson
title	Chiral DNA sequences as commutable controls for clinical genomics
title_short	Chiral DNA sequences as commutable controls for clinical genomics
title_full	Chiral DNA sequences as commutable controls for clinical genomics
title_fullStr	Chiral DNA sequences as commutable controls for clinical genomics
title_full_unstemmed	Chiral DNA sequences as commutable controls for clinical genomics
title_sort	chiral dna sequences as commutable controls for clinical genomics
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/eff97fe0e26c48849a3f468dba362eb7
work_keys_str_mv	AT irawdeveson chiraldnasequencesascommutablecontrolsforclinicalgenomics AT binduswapnamadala chiraldnasequencesascommutablecontrolsforclinicalgenomics AT jamesblackburn chiraldnasequencesascommutablecontrolsforclinicalgenomics AT chrisbarker chiraldnasequencesascommutablecontrolsforclinicalgenomics AT tedwong chiraldnasequencesascommutablecontrolsforclinicalgenomics AT kirstonmbarton chiraldnasequencesascommutablecontrolsforclinicalgenomics AT martinasmith chiraldnasequencesascommutablecontrolsforclinicalgenomics AT dneilwatkins chiraldnasequencesascommutablecontrolsforclinicalgenomics AT timrmercer chiraldnasequencesascommutablecontrolsforclinicalgenomics
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Chiral DNA sequences as commutable controls for clinical genomics

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