Chiral DNA sequences as commutable controls for clinical genomics

Any DNA sequence can be represented by a chiral partner sequence – an exact copy arranged in reverse nucleotide order. Here, the authors show that chiral DNA sequence pairs share important properties and show the utility of synthetic chiral sequences (sequins) as controls for clinical genomics.

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Autores principales: Ira W. Deveson, Bindu Swapna Madala, James Blackburn, Chris Barker, Ted Wong, Kirston M. Barton, Martin A. Smith, D. Neil Watkins, Tim R. Mercer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/eff97fe0e26c48849a3f468dba362eb7
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