Transmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand’s commercial poultry network

Understanding the relative contribution of different between-farm transmission pathways is essential in guiding recommendations for mitigating disease spread. This study investigated the association between contact pathways linking poultry farms in New Zealand and the genetic relatedness of antimicr...

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Autores principales:	Sabrina S. Greening, Ji Zhang, Anne C. Midwinter, David A. Wilkinson, Ahmed Fayaz, Deborah A. Williamson, Marti J. Anderson, M. Carolyn Gates, Nigel P. French
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Campylobacter jejuni Contact networks Phylodynamics PERMANOVA Correlation matrices Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/eff9a91b929c40328360f6876e73d29a
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spelling	oai:doaj.org-article:eff9a91b929c40328360f6876e73d29a2021-11-12T04:28:41ZTransmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand’s commercial poultry network1755-436510.1016/j.epidem.2021.100521https://doaj.org/article/eff9a91b929c40328360f6876e73d29a2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1755436521000670https://doaj.org/toc/1755-4365Understanding the relative contribution of different between-farm transmission pathways is essential in guiding recommendations for mitigating disease spread. This study investigated the association between contact pathways linking poultry farms in New Zealand and the genetic relatedness of antimicrobial resistant Campylobacter jejuni Sequence Type 6964 (ST-6964), with the aim of identifying the most likely contact pathways that contributed to its rapid spread across the industry. Whole-genome sequencing was performed on 167C. jejuni ST-6964 isolates sampled from across 30 New Zealand commercial poultry enterprises. The genetic relatedness between isolates was determined using whole genome multilocus sequence typing (wgMLST). Permutational multivariate analysis of variance and distance-based linear models were used to explore the strength of the relationship between pairwise genetic associations among the C. jejuni isolates and each of several pairwise distance matrices, indicating either the geographical distance between farms or the network distance of transportation vehicles. Overall, a significant association was found between the pairwise genetic relatedness of the C. jejuni isolates and the parent company, the road distance and the network distance of transporting feed vehicles. This result suggests that the transportation of feed within the commercial poultry industry as well as other local contacts between flocks, such as the movements of personnel, may have played a significant role in the spread of C. jejuni. However, further information on the historical contact patterns between farms is needed to fully characterise the risk of these pathways and to understand how they could be targeted to reduce the spread of C. jejuni.Sabrina S. GreeningJi ZhangAnne C. MidwinterDavid A. WilkinsonAhmed FayazDeborah A. WilliamsonMarti J. AndersonM. Carolyn GatesNigel P. FrenchElsevierarticleCampylobacter jejuniContact networksPhylodynamicsPERMANOVACorrelation matricesInfectious and parasitic diseasesRC109-216ENEpidemics, Vol 37, Iss , Pp 100521- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Campylobacter jejuni Contact networks Phylodynamics PERMANOVA Correlation matrices Infectious and parasitic diseases RC109-216
spellingShingle	Campylobacter jejuni Contact networks Phylodynamics PERMANOVA Correlation matrices Infectious and parasitic diseases RC109-216 Sabrina S. Greening Ji Zhang Anne C. Midwinter David A. Wilkinson Ahmed Fayaz Deborah A. Williamson Marti J. Anderson M. Carolyn Gates Nigel P. French Transmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand’s commercial poultry network
description	Understanding the relative contribution of different between-farm transmission pathways is essential in guiding recommendations for mitigating disease spread. This study investigated the association between contact pathways linking poultry farms in New Zealand and the genetic relatedness of antimicrobial resistant Campylobacter jejuni Sequence Type 6964 (ST-6964), with the aim of identifying the most likely contact pathways that contributed to its rapid spread across the industry. Whole-genome sequencing was performed on 167C. jejuni ST-6964 isolates sampled from across 30 New Zealand commercial poultry enterprises. The genetic relatedness between isolates was determined using whole genome multilocus sequence typing (wgMLST). Permutational multivariate analysis of variance and distance-based linear models were used to explore the strength of the relationship between pairwise genetic associations among the C. jejuni isolates and each of several pairwise distance matrices, indicating either the geographical distance between farms or the network distance of transportation vehicles. Overall, a significant association was found between the pairwise genetic relatedness of the C. jejuni isolates and the parent company, the road distance and the network distance of transporting feed vehicles. This result suggests that the transportation of feed within the commercial poultry industry as well as other local contacts between flocks, such as the movements of personnel, may have played a significant role in the spread of C. jejuni. However, further information on the historical contact patterns between farms is needed to fully characterise the risk of these pathways and to understand how they could be targeted to reduce the spread of C. jejuni.
format	article
author	Sabrina S. Greening Ji Zhang Anne C. Midwinter David A. Wilkinson Ahmed Fayaz Deborah A. Williamson Marti J. Anderson M. Carolyn Gates Nigel P. French
author_facet	Sabrina S. Greening Ji Zhang Anne C. Midwinter David A. Wilkinson Ahmed Fayaz Deborah A. Williamson Marti J. Anderson M. Carolyn Gates Nigel P. French
author_sort	Sabrina S. Greening
title	Transmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand’s commercial poultry network
title_short	Transmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand’s commercial poultry network
title_full	Transmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand’s commercial poultry network
title_fullStr	Transmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand’s commercial poultry network
title_full_unstemmed	Transmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand’s commercial poultry network
title_sort	transmission dynamics of an antimicrobial resistant campylobacter jejuni lineage in new zealand’s commercial poultry network
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/eff9a91b929c40328360f6876e73d29a
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Transmission dynamics of an antimicrobial resistant Campylobacter jejuni lineage in New Zealand’s commercial poultry network

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