Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex

The Legionella pneumophila Dot/Icm type IVB secretion system (T4BSS) translocates effector proteins into host cells, and the recognition of these effectors is mediated by the Dot/Icm type IV coupling protein (T4CP) complex. Here, the authors present the crystal structure of a four-subunit containing...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyunmin Kim, Tomoko Kubori, Kohei Yamazaki, Mi-Jeong Kwak, Suk-Youl Park, Hiroki Nagai, Joseph P. Vogel, Byung-Ha Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/effb78c716484c5e8bcb97dee0da7604
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:effb78c716484c5e8bcb97dee0da7604
record_format	dspace
spelling	oai:doaj.org-article:effb78c716484c5e8bcb97dee0da76042021-12-02T14:49:16ZStructural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex10.1038/s41467-020-16397-02041-1723https://doaj.org/article/effb78c716484c5e8bcb97dee0da76042020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16397-0https://doaj.org/toc/2041-1723The Legionella pneumophila Dot/Icm type IVB secretion system (T4BSS) translocates effector proteins into host cells, and the recognition of these effectors is mediated by the Dot/Icm type IV coupling protein (T4CP) complex. Here, the authors present the crystal structure of a four-subunit containing T4CP subcomplex bound to the effector protein VpdB, and identify a FxxxLxxxK binding motif that is present in a subset of the effectors and which is recognized by the T4CP adaptor subunit LvgA.Hyunmin KimTomoko KuboriKohei YamazakiMi-Jeong KwakSuk-Youl ParkHiroki NagaiJoseph P. VogelByung-Ha OhNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyunmin Kim Tomoko Kubori Kohei Yamazaki Mi-Jeong Kwak Suk-Youl Park Hiroki Nagai Joseph P. Vogel Byung-Ha Oh Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex
description	The Legionella pneumophila Dot/Icm type IVB secretion system (T4BSS) translocates effector proteins into host cells, and the recognition of these effectors is mediated by the Dot/Icm type IV coupling protein (T4CP) complex. Here, the authors present the crystal structure of a four-subunit containing T4CP subcomplex bound to the effector protein VpdB, and identify a FxxxLxxxK binding motif that is present in a subset of the effectors and which is recognized by the T4CP adaptor subunit LvgA.
format	article
author	Hyunmin Kim Tomoko Kubori Kohei Yamazaki Mi-Jeong Kwak Suk-Youl Park Hiroki Nagai Joseph P. Vogel Byung-Ha Oh
author_facet	Hyunmin Kim Tomoko Kubori Kohei Yamazaki Mi-Jeong Kwak Suk-Youl Park Hiroki Nagai Joseph P. Vogel Byung-Ha Oh
author_sort	Hyunmin Kim
title	Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex
title_short	Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex
title_full	Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex
title_fullStr	Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex
title_full_unstemmed	Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex
title_sort	structural basis for effector protein recognition by the dot/icm type ivb coupling protein complex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/effb78c716484c5e8bcb97dee0da7604
work_keys_str_mv	AT hyunminkim structuralbasisforeffectorproteinrecognitionbythedoticmtypeivbcouplingproteincomplex AT tomokokubori structuralbasisforeffectorproteinrecognitionbythedoticmtypeivbcouplingproteincomplex AT koheiyamazaki structuralbasisforeffectorproteinrecognitionbythedoticmtypeivbcouplingproteincomplex AT mijeongkwak structuralbasisforeffectorproteinrecognitionbythedoticmtypeivbcouplingproteincomplex AT sukyoulpark structuralbasisforeffectorproteinrecognitionbythedoticmtypeivbcouplingproteincomplex AT hirokinagai structuralbasisforeffectorproteinrecognitionbythedoticmtypeivbcouplingproteincomplex AT josephpvogel structuralbasisforeffectorproteinrecognitionbythedoticmtypeivbcouplingproteincomplex AT byunghaoh structuralbasisforeffectorproteinrecognitionbythedoticmtypeivbcouplingproteincomplex
_version_	1718389543180173312

Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex

Ejemplares similares