Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases

Abstract Ocular surface diseases (OSD) can cause serious visual deterioration and discomfort. Commercial artificial tear solution containing hyaluronic acid (HA) show excellent biocompatibility and unique viscoelastic characteristics. Here, we developed a novel HA membrane (HAM) by chemical crosslin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dong Ju Kim, Mi-Young Jung, Ha-Jin Pak, Joo-Hee Park, Martha Kim, Roy S. Chuck, Choul Yong Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/effb8fb41b86493b907ce6bb2b80c591
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:effb8fb41b86493b907ce6bb2b80c591
record_format	dspace
spelling	oai:doaj.org-article:effb8fb41b86493b907ce6bb2b80c5912021-12-02T13:24:17ZDevelopment of a novel hyaluronic acid membrane for the treatment of ocular surface diseases10.1038/s41598-021-81983-12045-2322https://doaj.org/article/effb8fb41b86493b907ce6bb2b80c5912021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81983-1https://doaj.org/toc/2045-2322Abstract Ocular surface diseases (OSD) can cause serious visual deterioration and discomfort. Commercial artificial tear solution containing hyaluronic acid (HA) show excellent biocompatibility and unique viscoelastic characteristics. Here, we developed a novel HA membrane (HAM) by chemical crosslinking using 1,4-butanediol diglycidyl ether for the effective treatment of OSDs. The main purpose of HAMs is to provide sustained release of HA to modulate the wound healing response in OSDs. The safety and efficacy of HAMs were investigated using primary cultured human corneal epithelial cells and various OSD rabbit models. In the dry state, the HAM is firm, transparent, and easy to manipulate. When hydrated, it swells rapidly with high water retention and over 90% transmission of visible light. Human corneal epithelial cells and rabbit eyes showed no toxic response to HAM. Addition of HAMs to the culture medium enhanced human corneal epithelial cell viability and expression of cell proliferation markers. Investigation of HAM wound healing efficacy using mechanical or chemical corneal trauma and conjunctival surgery in rabbits revealed that application of HAMs to the ocular surface enhanced healing of corneal epithelium and reduced corneal limbal vascularization, opacity and conjunctival fibrosis. The therapeutic potential of HAMs in various OSDs was successfully demonstrated.Dong Ju KimMi-Young JungHa-Jin PakJoo-Hee ParkMartha KimRoy S. ChuckChoul Yong ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong Ju Kim Mi-Young Jung Ha-Jin Pak Joo-Hee Park Martha Kim Roy S. Chuck Choul Yong Park Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases
description	Abstract Ocular surface diseases (OSD) can cause serious visual deterioration and discomfort. Commercial artificial tear solution containing hyaluronic acid (HA) show excellent biocompatibility and unique viscoelastic characteristics. Here, we developed a novel HA membrane (HAM) by chemical crosslinking using 1,4-butanediol diglycidyl ether for the effective treatment of OSDs. The main purpose of HAMs is to provide sustained release of HA to modulate the wound healing response in OSDs. The safety and efficacy of HAMs were investigated using primary cultured human corneal epithelial cells and various OSD rabbit models. In the dry state, the HAM is firm, transparent, and easy to manipulate. When hydrated, it swells rapidly with high water retention and over 90% transmission of visible light. Human corneal epithelial cells and rabbit eyes showed no toxic response to HAM. Addition of HAMs to the culture medium enhanced human corneal epithelial cell viability and expression of cell proliferation markers. Investigation of HAM wound healing efficacy using mechanical or chemical corneal trauma and conjunctival surgery in rabbits revealed that application of HAMs to the ocular surface enhanced healing of corneal epithelium and reduced corneal limbal vascularization, opacity and conjunctival fibrosis. The therapeutic potential of HAMs in various OSDs was successfully demonstrated.
format	article
author	Dong Ju Kim Mi-Young Jung Ha-Jin Pak Joo-Hee Park Martha Kim Roy S. Chuck Choul Yong Park
author_facet	Dong Ju Kim Mi-Young Jung Ha-Jin Pak Joo-Hee Park Martha Kim Roy S. Chuck Choul Yong Park
author_sort	Dong Ju Kim
title	Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases
title_short	Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases
title_full	Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases
title_fullStr	Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases
title_full_unstemmed	Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases
title_sort	development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/effb8fb41b86493b907ce6bb2b80c591
work_keys_str_mv	AT dongjukim developmentofanovelhyaluronicacidmembraneforthetreatmentofocularsurfacediseases AT miyoungjung developmentofanovelhyaluronicacidmembraneforthetreatmentofocularsurfacediseases AT hajinpak developmentofanovelhyaluronicacidmembraneforthetreatmentofocularsurfacediseases AT jooheepark developmentofanovelhyaluronicacidmembraneforthetreatmentofocularsurfacediseases AT marthakim developmentofanovelhyaluronicacidmembraneforthetreatmentofocularsurfacediseases AT royschuck developmentofanovelhyaluronicacidmembraneforthetreatmentofocularsurfacediseases AT choulyongpark developmentofanovelhyaluronicacidmembraneforthetreatmentofocularsurfacediseases
_version_	1718393127237058560

Development of a novel hyaluronic acid membrane for the treatment of ocular surface diseases

Ejemplares similares