Integrative epigenetic taxonomy of primary prostate cancer

Integrative epigenetic taxonomy of primary prostate cancer

The Androgen Receptor (AR) is the main driver of prostate cancer and functions in conjunction with chromatin modifications. Here, the authors comprehensively profile 100 primary prostate carcinomas by sequencing RNA transcripts in combination with ChIP-sequencing for AR and the active histone marks...

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Autores principales: Suzan Stelloo, Ekaterina Nevedomskaya, Yongsoo Kim, Karianne Schuurman, Eider Valle-Encinas, João Lobo, Oscar Krijgsman, Daniel Simon Peeper, Seiwon Laura Chang, Felix Yi-Chung Feng, Lodewyk Frederik Ary Wessels, Rui Henrique, Carmen Jerónimo, Andries Marinus Bergman, Wilbert Zwart
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/effc0af426e44531a865abc7a1346937
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spelling oai:doaj.org-article:effc0af426e44531a865abc7a13469372021-12-02T15:34:42ZIntegrative epigenetic taxonomy of primary prostate cancer10.1038/s41467-018-07270-22041-1723https://doaj.org/article/effc0af426e44531a865abc7a13469372018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07270-2https://doaj.org/toc/2041-1723The Androgen Receptor (AR) is the main driver of prostate cancer and functions in conjunction with chromatin modifications. Here, the authors comprehensively profile 100 primary prostate carcinomas by sequencing RNA transcripts in combination with ChIP-sequencing for AR and the active histone marks H3K27ac, H3K4me3 and repressive mark H3K27me3.Suzan StellooEkaterina NevedomskayaYongsoo KimKarianne SchuurmanEider Valle-EncinasJoão LoboOscar KrijgsmanDaniel Simon PeeperSeiwon Laura ChangFelix Yi-Chung FengLodewyk Frederik Ary WesselsRui HenriqueCarmen JerónimoAndries Marinus BergmanWilbert ZwartNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Suzan Stelloo
Ekaterina Nevedomskaya
Yongsoo Kim
Karianne Schuurman
Eider Valle-Encinas
João Lobo
Oscar Krijgsman
Daniel Simon Peeper
Seiwon Laura Chang
Felix Yi-Chung Feng
Lodewyk Frederik Ary Wessels
Rui Henrique
Carmen Jerónimo
Andries Marinus Bergman
Wilbert Zwart
Integrative epigenetic taxonomy of primary prostate cancer
description The Androgen Receptor (AR) is the main driver of prostate cancer and functions in conjunction with chromatin modifications. Here, the authors comprehensively profile 100 primary prostate carcinomas by sequencing RNA transcripts in combination with ChIP-sequencing for AR and the active histone marks H3K27ac, H3K4me3 and repressive mark H3K27me3.
format article
author Suzan Stelloo
Ekaterina Nevedomskaya
Yongsoo Kim
Karianne Schuurman
Eider Valle-Encinas
João Lobo
Oscar Krijgsman
Daniel Simon Peeper
Seiwon Laura Chang
Felix Yi-Chung Feng
Lodewyk Frederik Ary Wessels
Rui Henrique
Carmen Jerónimo
Andries Marinus Bergman
Wilbert Zwart
author_facet Suzan Stelloo
Ekaterina Nevedomskaya
Yongsoo Kim
Karianne Schuurman
Eider Valle-Encinas
João Lobo
Oscar Krijgsman
Daniel Simon Peeper
Seiwon Laura Chang
Felix Yi-Chung Feng
Lodewyk Frederik Ary Wessels
Rui Henrique
Carmen Jerónimo
Andries Marinus Bergman
Wilbert Zwart
author_sort Suzan Stelloo
title Integrative epigenetic taxonomy of primary prostate cancer
title_short Integrative epigenetic taxonomy of primary prostate cancer
title_full Integrative epigenetic taxonomy of primary prostate cancer
title_fullStr Integrative epigenetic taxonomy of primary prostate cancer
title_full_unstemmed Integrative epigenetic taxonomy of primary prostate cancer
title_sort integrative epigenetic taxonomy of primary prostate cancer
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/effc0af426e44531a865abc7a1346937
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