Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

In mammals, DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B. Here the authors report the crystal structures of DNMT3B in complex with both CpG and CpA DNA, providing insight into the substrate-recognition mechanism underpinning the divergent genomic...

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Autores principales: Linfeng Gao, Max Emperle, Yiran Guo, Sara A. Grimm, Wendan Ren, Sabrina Adam, Hidetaka Uryu, Zhi-Min Zhang, Dongliang Chen, Jiekai Yin, Michael Dukatz, Hiwot Anteneh, Renata Z. Jurkowska, Jiuwei Lu, Yinsheng Wang, Pavel Bashtrykov, Paul A. Wade, Gang Greg Wang, Albert Jeltsch, Jikui Song
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/effe2dab19bf4176b1b1739202fca190
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spelling oai:doaj.org-article:effe2dab19bf4176b1b1739202fca1902021-12-02T18:18:35ZComprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms10.1038/s41467-020-17109-42041-1723https://doaj.org/article/effe2dab19bf4176b1b1739202fca1902020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17109-4https://doaj.org/toc/2041-1723In mammals, DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B. Here the authors report the crystal structures of DNMT3B in complex with both CpG and CpA DNA, providing insight into the substrate-recognition mechanism underpinning the divergent genomic methylation activities of DNMT3A and DNMT3B.Linfeng GaoMax EmperleYiran GuoSara A. GrimmWendan RenSabrina AdamHidetaka UryuZhi-Min ZhangDongliang ChenJiekai YinMichael DukatzHiwot AntenehRenata Z. JurkowskaJiuwei LuYinsheng WangPavel BashtrykovPaul A. WadeGang Greg WangAlbert JeltschJikui SongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Linfeng Gao
Max Emperle
Yiran Guo
Sara A. Grimm
Wendan Ren
Sabrina Adam
Hidetaka Uryu
Zhi-Min Zhang
Dongliang Chen
Jiekai Yin
Michael Dukatz
Hiwot Anteneh
Renata Z. Jurkowska
Jiuwei Lu
Yinsheng Wang
Pavel Bashtrykov
Paul A. Wade
Gang Greg Wang
Albert Jeltsch
Jikui Song
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
description In mammals, DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B. Here the authors report the crystal structures of DNMT3B in complex with both CpG and CpA DNA, providing insight into the substrate-recognition mechanism underpinning the divergent genomic methylation activities of DNMT3A and DNMT3B.
format article
author Linfeng Gao
Max Emperle
Yiran Guo
Sara A. Grimm
Wendan Ren
Sabrina Adam
Hidetaka Uryu
Zhi-Min Zhang
Dongliang Chen
Jiekai Yin
Michael Dukatz
Hiwot Anteneh
Renata Z. Jurkowska
Jiuwei Lu
Yinsheng Wang
Pavel Bashtrykov
Paul A. Wade
Gang Greg Wang
Albert Jeltsch
Jikui Song
author_facet Linfeng Gao
Max Emperle
Yiran Guo
Sara A. Grimm
Wendan Ren
Sabrina Adam
Hidetaka Uryu
Zhi-Min Zhang
Dongliang Chen
Jiekai Yin
Michael Dukatz
Hiwot Anteneh
Renata Z. Jurkowska
Jiuwei Lu
Yinsheng Wang
Pavel Bashtrykov
Paul A. Wade
Gang Greg Wang
Albert Jeltsch
Jikui Song
author_sort Linfeng Gao
title Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
title_short Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
title_full Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
title_fullStr Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
title_full_unstemmed Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
title_sort comprehensive structure-function characterization of dnmt3b and dnmt3a reveals distinctive de novo dna methylation mechanisms
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/effe2dab19bf4176b1b1739202fca190
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