Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases

Abstract Most human diseases are systems diseases, and systems biomarkers are better fitted for diagnostic, prognostic, and treatment monitoring purposes. To search for systems biomarker candidates, lactate dehydrogenase (LDH), a housekeeping protein expressed in all living cells, was investigated....

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Autores principales:	Yuling Wu, Caixia Lu, Nana Pan, Meng Zhang, Yi An, Mengyuan Xu, Lijuan Zhang, Yachong Guo, Lijuan Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/effe595dceb94e1eb4f749802ea00a21
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spelling	oai:doaj.org-article:effe595dceb94e1eb4f749802ea00a212021-12-02T17:45:17ZSerum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases10.1038/s41598-021-92430-62045-2322https://doaj.org/article/effe595dceb94e1eb4f749802ea00a212021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92430-6https://doaj.org/toc/2045-2322Abstract Most human diseases are systems diseases, and systems biomarkers are better fitted for diagnostic, prognostic, and treatment monitoring purposes. To search for systems biomarker candidates, lactate dehydrogenase (LDH), a housekeeping protein expressed in all living cells, was investigated. To this end, we analyzed the serum LDH activities from 172,933 patients with 48 clinically defined diseases and 9528 healthy individuals. Based on the median values, we found that 46 out of 48 diseases, leading by acute myocardial infarction, had significantly increased (p < 0.001), whereas gout and cerebral ischemia had significantly decreased (p < 0.001) serum LDH activities compared to the healthy control. Remarkably, hepatic encephalopathy and lung fibrosis had the highest AUCs (0.89, 0.80), sensitivities (0.73, 0.56), and specificities (0.90, 0.91) among 48 human diseases. Statistical analysis revealed that over-downregulation of serum LDH activities was associated with blood-related cancers and diseases. LDH activities were potential systems biomarker candidates (AUCs > 0.8) for hepatic encephalopathy and lung fibrosis.Yuling WuCaixia LuNana PanMeng ZhangYi AnMengyuan XuLijuan ZhangYachong GuoLijuan TanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuling Wu Caixia Lu Nana Pan Meng Zhang Yi An Mengyuan Xu Lijuan Zhang Yachong Guo Lijuan Tan Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases
description	Abstract Most human diseases are systems diseases, and systems biomarkers are better fitted for diagnostic, prognostic, and treatment monitoring purposes. To search for systems biomarker candidates, lactate dehydrogenase (LDH), a housekeeping protein expressed in all living cells, was investigated. To this end, we analyzed the serum LDH activities from 172,933 patients with 48 clinically defined diseases and 9528 healthy individuals. Based on the median values, we found that 46 out of 48 diseases, leading by acute myocardial infarction, had significantly increased (p < 0.001), whereas gout and cerebral ischemia had significantly decreased (p < 0.001) serum LDH activities compared to the healthy control. Remarkably, hepatic encephalopathy and lung fibrosis had the highest AUCs (0.89, 0.80), sensitivities (0.73, 0.56), and specificities (0.90, 0.91) among 48 human diseases. Statistical analysis revealed that over-downregulation of serum LDH activities was associated with blood-related cancers and diseases. LDH activities were potential systems biomarker candidates (AUCs > 0.8) for hepatic encephalopathy and lung fibrosis.
format	article
author	Yuling Wu Caixia Lu Nana Pan Meng Zhang Yi An Mengyuan Xu Lijuan Zhang Yachong Guo Lijuan Tan
author_facet	Yuling Wu Caixia Lu Nana Pan Meng Zhang Yi An Mengyuan Xu Lijuan Zhang Yachong Guo Lijuan Tan
author_sort	Yuling Wu
title	Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases
title_short	Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases
title_full	Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases
title_fullStr	Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases
title_full_unstemmed	Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases
title_sort	serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/effe595dceb94e1eb4f749802ea00a21
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Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases

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