Neural and behavioural correlates of repeated social defeat

Abstract Dominance hierarchies are common across the animal kingdom and have important consequences for reproduction and survival. Animals of lower social status cope with repeated social defeat using proactive and reactive behaviours. However, there remains a paucity of information on how an indivi...

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Autores principales:	Julie M. Butler, Sarah M. Whitlow, David A. Roberts, Karen P. Maruska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/efff9c4aff944e9ba4472f426a42596f
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spelling	oai:doaj.org-article:efff9c4aff944e9ba4472f426a42596f2021-12-02T12:33:00ZNeural and behavioural correlates of repeated social defeat10.1038/s41598-018-25160-x2045-2322https://doaj.org/article/efff9c4aff944e9ba4472f426a42596f2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25160-xhttps://doaj.org/toc/2045-2322Abstract Dominance hierarchies are common across the animal kingdom and have important consequences for reproduction and survival. Animals of lower social status cope with repeated social defeat using proactive and reactive behaviours. However, there remains a paucity of information on how an individual’s coping behaviours changes over time or what neural mechanisms are involved. We used a resident-intruder paradigm in the African cichlid fish Astatotilapia burtoni to investigate the neural correlates of these two opposing behaviour groups. Fish initially used both proactive and reactive behaviours, but had a dramatic increase in use of proactive behaviours during the third interaction, and this was followed by cessation of proactive behaviours and exclusive use of reactive coping. By quantifying neural activation in socially-relevant brain regions, we identify a subset of brain nuclei, including those homologous to the mammalian amygdala, showing higher activation in fish displaying proactive but not reactive behaviours. Fish displaying reactive behaviours had greater neural activation in the superior raphe, suggesting a possible conserved function during social defeat across vertebrates. These data provide the first evidence on the involvement of specific brain regions underlying proactive and reactive coping in fishes, indicating that these nuclei have conserved functions during social defeat across taxa.Julie M. ButlerSarah M. WhitlowDavid A. RobertsKaren P. MaruskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julie M. Butler Sarah M. Whitlow David A. Roberts Karen P. Maruska Neural and behavioural correlates of repeated social defeat
description	Abstract Dominance hierarchies are common across the animal kingdom and have important consequences for reproduction and survival. Animals of lower social status cope with repeated social defeat using proactive and reactive behaviours. However, there remains a paucity of information on how an individual’s coping behaviours changes over time or what neural mechanisms are involved. We used a resident-intruder paradigm in the African cichlid fish Astatotilapia burtoni to investigate the neural correlates of these two opposing behaviour groups. Fish initially used both proactive and reactive behaviours, but had a dramatic increase in use of proactive behaviours during the third interaction, and this was followed by cessation of proactive behaviours and exclusive use of reactive coping. By quantifying neural activation in socially-relevant brain regions, we identify a subset of brain nuclei, including those homologous to the mammalian amygdala, showing higher activation in fish displaying proactive but not reactive behaviours. Fish displaying reactive behaviours had greater neural activation in the superior raphe, suggesting a possible conserved function during social defeat across vertebrates. These data provide the first evidence on the involvement of specific brain regions underlying proactive and reactive coping in fishes, indicating that these nuclei have conserved functions during social defeat across taxa.
format	article
author	Julie M. Butler Sarah M. Whitlow David A. Roberts Karen P. Maruska
author_facet	Julie M. Butler Sarah M. Whitlow David A. Roberts Karen P. Maruska
author_sort	Julie M. Butler
title	Neural and behavioural correlates of repeated social defeat
title_short	Neural and behavioural correlates of repeated social defeat
title_full	Neural and behavioural correlates of repeated social defeat
title_fullStr	Neural and behavioural correlates of repeated social defeat
title_full_unstemmed	Neural and behavioural correlates of repeated social defeat
title_sort	neural and behavioural correlates of repeated social defeat
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/efff9c4aff944e9ba4472f426a42596f
work_keys_str_mv	AT juliembutler neuralandbehaviouralcorrelatesofrepeatedsocialdefeat AT sarahmwhitlow neuralandbehaviouralcorrelatesofrepeatedsocialdefeat AT davidaroberts neuralandbehaviouralcorrelatesofrepeatedsocialdefeat AT karenpmaruska neuralandbehaviouralcorrelatesofrepeatedsocialdefeat
_version_	1718393894300811264

Neural and behavioural correlates of repeated social defeat

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