Bioactive molecules for regenerative pulp capping

Since the discovery of bioactive molecules sequestered in dentine, researchers have been exploring ways to harness their activities for dental regeneration. One specific area, discussed in this review, is that of dental-pulp capping. Dental-pulp caps are placed when the dental pulp is exposed due to...

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Autores principales:	LLE Whitehouse, NH Thomson, T Do, GA Feichtinger
Formato:	article
Lenguaje:	EN
Publicado:	AO Research Institute Davos 2021
Materias:	dental pulp pulp cappping pulp regeneration biologics biomaterials growth factors dentistry dentinogenesis regenerative medicine Surgery RD1-811 Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/f00045a70fb34a39a3e7e3ab33907fef
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id	oai:doaj.org-article:f00045a70fb34a39a3e7e3ab33907fef
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spelling	oai:doaj.org-article:f00045a70fb34a39a3e7e3ab33907fef2021-11-29T13:01:21ZBioactive molecules for regenerative pulp capping10.22203/eCM.v042a261473-2262https://doaj.org/article/f00045a70fb34a39a3e7e3ab33907fef2021-11-01T00:00:00Zhttps://www.ecmjournal.org/papers/vol042/pdf/v042a26.pdfhttps://doaj.org/toc/1473-2262Since the discovery of bioactive molecules sequestered in dentine, researchers have been exploring ways to harness their activities for dental regeneration. One specific area, discussed in this review, is that of dental-pulp capping. Dental-pulp caps are placed when the dental pulp is exposed due to decay or trauma in an attempt to enhance tertiary dentine deposition. Several materials are used for dental-pulp capping; however, natural biomimetic scaffolds may offer advantages over manufactured materials such as improved aesthetic, biocompatibility and success rate. The present review discusses and appraises the current evidence surrounding biomimetic dental-pulp capping, with a focus on bioactive molecules sequestered in dentine. Molecules covered most extensively in the literature include transforming growth factors (TGF-βs, specifically TGF-β1) and bone morphogenetic proteins (BMPs, specifically BMP-2 and BMP-7). Further studies would need to explore the synergistic use of multiple peptides together with the development of a tailored scaffold carrier. The roles of some of the molecules identified in dentine need to be explored before they can be considered as potential bioactive molecules in a biomimetic scaffold for dental-pulp capping. Future in vivo work needs to consider the inflammatory environment of the dental pulp in pulpal exposures and compare pulp-capping materials.LLE WhitehouseNH ThomsonT DoGA Feichtinger AO Research Institute Davosarticledental pulppulp capppingpulp regenerationbiologicsbiomaterialsgrowth factorsdentistrydentinogenesisregenerative medicineSurgeryRD1-811Diseases of the musculoskeletal systemRC925-935ENEuropean Cells & Materials, Vol 42, Pp 415-437 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dental pulp pulp cappping pulp regeneration biologics biomaterials growth factors dentistry dentinogenesis regenerative medicine Surgery RD1-811 Diseases of the musculoskeletal system RC925-935
spellingShingle	dental pulp pulp cappping pulp regeneration biologics biomaterials growth factors dentistry dentinogenesis regenerative medicine Surgery RD1-811 Diseases of the musculoskeletal system RC925-935 LLE Whitehouse NH Thomson T Do GA Feichtinger Bioactive molecules for regenerative pulp capping
description	Since the discovery of bioactive molecules sequestered in dentine, researchers have been exploring ways to harness their activities for dental regeneration. One specific area, discussed in this review, is that of dental-pulp capping. Dental-pulp caps are placed when the dental pulp is exposed due to decay or trauma in an attempt to enhance tertiary dentine deposition. Several materials are used for dental-pulp capping; however, natural biomimetic scaffolds may offer advantages over manufactured materials such as improved aesthetic, biocompatibility and success rate. The present review discusses and appraises the current evidence surrounding biomimetic dental-pulp capping, with a focus on bioactive molecules sequestered in dentine. Molecules covered most extensively in the literature include transforming growth factors (TGF-βs, specifically TGF-β1) and bone morphogenetic proteins (BMPs, specifically BMP-2 and BMP-7). Further studies would need to explore the synergistic use of multiple peptides together with the development of a tailored scaffold carrier. The roles of some of the molecules identified in dentine need to be explored before they can be considered as potential bioactive molecules in a biomimetic scaffold for dental-pulp capping. Future in vivo work needs to consider the inflammatory environment of the dental pulp in pulpal exposures and compare pulp-capping materials.
format	article
author	LLE Whitehouse NH Thomson T Do GA Feichtinger
author_facet	LLE Whitehouse NH Thomson T Do GA Feichtinger
author_sort	LLE Whitehouse
title	Bioactive molecules for regenerative pulp capping
title_short	Bioactive molecules for regenerative pulp capping
title_full	Bioactive molecules for regenerative pulp capping
title_fullStr	Bioactive molecules for regenerative pulp capping
title_full_unstemmed	Bioactive molecules for regenerative pulp capping
title_sort	bioactive molecules for regenerative pulp capping
publisher	AO Research Institute Davos
publishDate	2021
url	https://doaj.org/article/f00045a70fb34a39a3e7e3ab33907fef
work_keys_str_mv	AT llewhitehouse bioactivemoleculesforregenerativepulpcapping AT nhthomson bioactivemoleculesforregenerativepulpcapping AT tdo bioactivemoleculesforregenerativepulpcapping AT gafeichtinger bioactivemoleculesforregenerativepulpcapping
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Bioactive molecules for regenerative pulp capping

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