9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy
The molecular mechanisms of resistance to immune checkpoint therapy remain elusive. Here, the authors perform immunogenomic analysis of TCGA data and data from clinical trials for antiPD-1/PD-L1 therapy and highlight the association of 9p21 loss with a cold tumor microenvironment and resistance to t...
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Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | article |
Langue: | EN |
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Nature Portfolio
2021
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Accès en ligne: | https://doaj.org/article/f000b69e3fbd4f02bc414de145aab9e8 |
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