СHANGES OF TLR GENE EXPRESSION IN CERVICAL EPITHELIUM FROM THE PATIENTS WITH UROGENITAL INFLAMMATORY DISEASES

Toll-like receptors (TLR) are involved into innate immune recognition of microorganisms, including pathogenic bacteria. The aim of this work is to assess relative levels of TLR2 and TLR9 expression in cervical epithelial cells of women with inflammatory diseases of pelvic organs. The total group of...

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Autores principales:	O. A. Svitich, L. I. Krasnoproshina, L. V. Gankovskaya, L. V. Shibina, I. I. Zaitseva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	immunity toll-like receptor urogenital infection inflammatory diseases Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f002053e21814d358455f4848aff2e09
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spelling	oai:doaj.org-article:f002053e21814d358455f4848aff2e092021-11-18T08:03:44ZСHANGES OF TLR GENE EXPRESSION IN CERVICAL EPITHELIUM FROM THE PATIENTS WITH UROGENITAL INFLAMMATORY DISEASES1563-06252313-741X10.15789/1563-0625-2015-3-269-274https://doaj.org/article/f002053e21814d358455f4848aff2e092015-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/892https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XToll-like receptors (TLR) are involved into innate immune recognition of microorganisms, including pathogenic bacteria. The aim of this work is to assess relative levels of TLR2 and TLR9 expression in cervical epithelial cells of women with inflammatory diseases of pelvic organs. The total group of patients consisted of 47 persons, including 20 women with urogenital infections, and 27 women comprised a control group. Using real-time PCR, we identified the opportunistic pathogens and gene expression levels of TLR2, TLR9 in the cervix epithelial cells. It was shown that expression of TLR9 in the group with urogenital infections was 13.7-fold higher than in control group. We have revealed that a significant increase of TLR9 expression in the mucosal epithelium from cervical canal correlated with detection of infectious pathogens in the samples.O. A. SvitichL. I. KrasnoproshinaL. V. GankovskayaL. V. ShibinaI. I. ZaitsevaSPb RAACIarticleimmunitytoll-like receptorurogenital infectioninflammatory diseasesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 3, Pp 269-274 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunity toll-like receptor urogenital infection inflammatory diseases Immunologic diseases. Allergy RC581-607
spellingShingle	immunity toll-like receptor urogenital infection inflammatory diseases Immunologic diseases. Allergy RC581-607 O. A. Svitich L. I. Krasnoproshina L. V. Gankovskaya L. V. Shibina I. I. Zaitseva СHANGES OF TLR GENE EXPRESSION IN CERVICAL EPITHELIUM FROM THE PATIENTS WITH UROGENITAL INFLAMMATORY DISEASES
description	Toll-like receptors (TLR) are involved into innate immune recognition of microorganisms, including pathogenic bacteria. The aim of this work is to assess relative levels of TLR2 and TLR9 expression in cervical epithelial cells of women with inflammatory diseases of pelvic organs. The total group of patients consisted of 47 persons, including 20 women with urogenital infections, and 27 women comprised a control group. Using real-time PCR, we identified the opportunistic pathogens and gene expression levels of TLR2, TLR9 in the cervix epithelial cells. It was shown that expression of TLR9 in the group with urogenital infections was 13.7-fold higher than in control group. We have revealed that a significant increase of TLR9 expression in the mucosal epithelium from cervical canal correlated with detection of infectious pathogens in the samples.
format	article
author	O. A. Svitich L. I. Krasnoproshina L. V. Gankovskaya L. V. Shibina I. I. Zaitseva
author_facet	O. A. Svitich L. I. Krasnoproshina L. V. Gankovskaya L. V. Shibina I. I. Zaitseva
author_sort	O. A. Svitich
title	СHANGES OF TLR GENE EXPRESSION IN CERVICAL EPITHELIUM FROM THE PATIENTS WITH UROGENITAL INFLAMMATORY DISEASES
title_short	СHANGES OF TLR GENE EXPRESSION IN CERVICAL EPITHELIUM FROM THE PATIENTS WITH UROGENITAL INFLAMMATORY DISEASES
title_full	СHANGES OF TLR GENE EXPRESSION IN CERVICAL EPITHELIUM FROM THE PATIENTS WITH UROGENITAL INFLAMMATORY DISEASES
title_fullStr	СHANGES OF TLR GENE EXPRESSION IN CERVICAL EPITHELIUM FROM THE PATIENTS WITH UROGENITAL INFLAMMATORY DISEASES
title_full_unstemmed	СHANGES OF TLR GENE EXPRESSION IN CERVICAL EPITHELIUM FROM THE PATIENTS WITH UROGENITAL INFLAMMATORY DISEASES
title_sort	сhanges of tlr gene expression in cervical epithelium from the patients with urogenital inflammatory diseases
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/f002053e21814d358455f4848aff2e09
work_keys_str_mv	AT oasvitich shangesoftlrgeneexpressionincervicalepitheliumfromthepatientswithurogenitalinflammatorydiseases AT likrasnoproshina shangesoftlrgeneexpressionincervicalepitheliumfromthepatientswithurogenitalinflammatorydiseases AT lvgankovskaya shangesoftlrgeneexpressionincervicalepitheliumfromthepatientswithurogenitalinflammatorydiseases AT lvshibina shangesoftlrgeneexpressionincervicalepitheliumfromthepatientswithurogenitalinflammatorydiseases AT iizaitseva shangesoftlrgeneexpressionincervicalepitheliumfromthepatientswithurogenitalinflammatorydiseases
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СHANGES OF TLR GENE EXPRESSION IN CERVICAL EPITHELIUM FROM THE PATIENTS WITH UROGENITAL INFLAMMATORY DISEASES

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