Motor function and white matter connectivity in children cooled for neonatal encephalopathy

Therapeutic hypothermia reduces the incidence of severe motor disability, such as cerebral palsy, following neonatal hypoxic-ischaemic encephalopathy. However, cooled children without cerebral palsy at school-age demonstrate motor deficits and altered white matter connectivity. In this study, we use...

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Autores principales:	Arthur P.C. Spencer, Jonathan C.W. Brooks, Naoki Masuda, Hollie Byrne, Richard Lee-Kelland, Sally Jary, Marianne Thoresen, Marc Goodfellow, Frances M. Cowan, Ela Chakkarapani
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Therapeutic hypothermia Neonatal encephalopathy Structural connectivity Brain networks Motor ability Fractional anisotropy Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f002679766df4fe6850e9aef775487a4
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spelling	oai:doaj.org-article:f002679766df4fe6850e9aef775487a42021-11-06T04:28:05ZMotor function and white matter connectivity in children cooled for neonatal encephalopathy2213-158210.1016/j.nicl.2021.102872https://doaj.org/article/f002679766df4fe6850e9aef775487a42021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003168https://doaj.org/toc/2213-1582Therapeutic hypothermia reduces the incidence of severe motor disability, such as cerebral palsy, following neonatal hypoxic-ischaemic encephalopathy. However, cooled children without cerebral palsy at school-age demonstrate motor deficits and altered white matter connectivity. In this study, we used diffusion-weighted imaging to investigate the relationship between white matter connectivity and motor performance, measured using the Movement Assessment Battery for Children-2, in children aged 6–8 years treated with therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy at birth, who did not develop cerebral palsy (cases), and matched typically developing controls. Correlations between total motor scores and diffusion properties in major white matter tracts were assessed in 33 cases and 36 controls. In cases, significant correlations (FDR-corrected P < 0.05) were found in the anterior thalamic radiation bilaterally (left: r = 0.513; right: r = 0.488), the cingulate gyrus part of the left cingulum (r = 0.588), the hippocampal part of the left cingulum (r = 0.541), and the inferior fronto-occipital fasciculus bilaterally (left: r = 0.445; right: r = 0.494). No significant correlations were found in controls. We then constructed structural connectivity networks, for 22 cases and 32 controls, in which nodes represent brain regions and edges were determined by probabilistic tractography and weighted by fractional anisotropy. Analysis of whole-brain network metrics revealed correlations (FDR-corrected P < 0.05), in cases, between total motor scores and average node strength (r = 0.571), local efficiency (r = 0.664), global efficiency (r = 0.677), clustering coefficient (r = 0.608), and characteristic path length (r = -0.652). No significant correlations were found in controls. We then investigated edge-level association with motor function using the network-based statistic. This revealed subnetworks which exhibited group differences in the association between motor outcome and edge weights, for total motor scores (P = 0.0109) as well as for balance (P = 0.0245) and manual dexterity (P = 0.0233) domain scores. All three of these subnetworks comprised numerous frontal lobe regions known to be associated with motor function, including the superior frontal gyrus and middle frontal gyrus. The subnetwork associated with total motor scores was highly left-lateralised. These findings demonstrate an association between impaired motor function and brain organisation in school-age children treated with therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy.Arthur P.C. SpencerJonathan C.W. BrooksNaoki MasudaHollie ByrneRichard Lee-KellandSally JaryMarianne ThoresenMarc GoodfellowFrances M. CowanEla ChakkarapaniElsevierarticleTherapeutic hypothermiaNeonatal encephalopathyStructural connectivityBrain networksMotor abilityFractional anisotropyComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102872- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutic hypothermia Neonatal encephalopathy Structural connectivity Brain networks Motor ability Fractional anisotropy Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Therapeutic hypothermia Neonatal encephalopathy Structural connectivity Brain networks Motor ability Fractional anisotropy Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Arthur P.C. Spencer Jonathan C.W. Brooks Naoki Masuda Hollie Byrne Richard Lee-Kelland Sally Jary Marianne Thoresen Marc Goodfellow Frances M. Cowan Ela Chakkarapani Motor function and white matter connectivity in children cooled for neonatal encephalopathy
description	Therapeutic hypothermia reduces the incidence of severe motor disability, such as cerebral palsy, following neonatal hypoxic-ischaemic encephalopathy. However, cooled children without cerebral palsy at school-age demonstrate motor deficits and altered white matter connectivity. In this study, we used diffusion-weighted imaging to investigate the relationship between white matter connectivity and motor performance, measured using the Movement Assessment Battery for Children-2, in children aged 6–8 years treated with therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy at birth, who did not develop cerebral palsy (cases), and matched typically developing controls. Correlations between total motor scores and diffusion properties in major white matter tracts were assessed in 33 cases and 36 controls. In cases, significant correlations (FDR-corrected P < 0.05) were found in the anterior thalamic radiation bilaterally (left: r = 0.513; right: r = 0.488), the cingulate gyrus part of the left cingulum (r = 0.588), the hippocampal part of the left cingulum (r = 0.541), and the inferior fronto-occipital fasciculus bilaterally (left: r = 0.445; right: r = 0.494). No significant correlations were found in controls. We then constructed structural connectivity networks, for 22 cases and 32 controls, in which nodes represent brain regions and edges were determined by probabilistic tractography and weighted by fractional anisotropy. Analysis of whole-brain network metrics revealed correlations (FDR-corrected P < 0.05), in cases, between total motor scores and average node strength (r = 0.571), local efficiency (r = 0.664), global efficiency (r = 0.677), clustering coefficient (r = 0.608), and characteristic path length (r = -0.652). No significant correlations were found in controls. We then investigated edge-level association with motor function using the network-based statistic. This revealed subnetworks which exhibited group differences in the association between motor outcome and edge weights, for total motor scores (P = 0.0109) as well as for balance (P = 0.0245) and manual dexterity (P = 0.0233) domain scores. All three of these subnetworks comprised numerous frontal lobe regions known to be associated with motor function, including the superior frontal gyrus and middle frontal gyrus. The subnetwork associated with total motor scores was highly left-lateralised. These findings demonstrate an association between impaired motor function and brain organisation in school-age children treated with therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy.
format	article
author	Arthur P.C. Spencer Jonathan C.W. Brooks Naoki Masuda Hollie Byrne Richard Lee-Kelland Sally Jary Marianne Thoresen Marc Goodfellow Frances M. Cowan Ela Chakkarapani
author_facet	Arthur P.C. Spencer Jonathan C.W. Brooks Naoki Masuda Hollie Byrne Richard Lee-Kelland Sally Jary Marianne Thoresen Marc Goodfellow Frances M. Cowan Ela Chakkarapani
author_sort	Arthur P.C. Spencer
title	Motor function and white matter connectivity in children cooled for neonatal encephalopathy
title_short	Motor function and white matter connectivity in children cooled for neonatal encephalopathy
title_full	Motor function and white matter connectivity in children cooled for neonatal encephalopathy
title_fullStr	Motor function and white matter connectivity in children cooled for neonatal encephalopathy
title_full_unstemmed	Motor function and white matter connectivity in children cooled for neonatal encephalopathy
title_sort	motor function and white matter connectivity in children cooled for neonatal encephalopathy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f002679766df4fe6850e9aef775487a4
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Motor function and white matter connectivity in children cooled for neonatal encephalopathy

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