Cerebellar complex spikes multiplex complementary behavioral information.

Purkinje cell (PC) discharge, the only output of cerebellar cortex, involves 2 types of action potentials, high-frequency simple spikes (SSs) and low-frequency complex spikes (CSs). While there is consensus that SSs convey information needed to optimize movement kinematics, the function of CSs, dete...

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Autores principales:	Akshay Markanday, Junya Inoue, Peter W Dicke, Peter Thier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f0041c9dc35f4c8aba57fe9cc6a5318f
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id	oai:doaj.org-article:f0041c9dc35f4c8aba57fe9cc6a5318f
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spelling	oai:doaj.org-article:f0041c9dc35f4c8aba57fe9cc6a5318f2021-12-02T19:54:35ZCerebellar complex spikes multiplex complementary behavioral information.1544-91731545-788510.1371/journal.pbio.3001400https://doaj.org/article/f0041c9dc35f4c8aba57fe9cc6a5318f2021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001400https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Purkinje cell (PC) discharge, the only output of cerebellar cortex, involves 2 types of action potentials, high-frequency simple spikes (SSs) and low-frequency complex spikes (CSs). While there is consensus that SSs convey information needed to optimize movement kinematics, the function of CSs, determined by the PC's climbing fiber input, remains controversial. While initially thought to be specialized in reporting information on motor error for the subsequent amendment of behavior, CSs seem to contribute to other aspects of motor behavior as well. When faced with the bewildering diversity of findings and views unraveled by highly specific tasks, one may wonder if there is just one true function with all the other attributions wrong? Or is the diversity of findings a reflection of distinct pools of PCs, each processing specific streams of information conveyed by climbing fibers? With these questions in mind, we recorded CSs from the monkey oculomotor vermis deploying a repetitive saccade task that entailed sizable motor errors as well as small amplitude saccades, correcting them. We demonstrate that, in addition to carrying error-related information, CSs carry information on the metrics of both primary and small corrective saccades in a time-specific manner, with changes in CS firing probability coupled with changes in CS duration. Furthermore, we also found CS activity that seemed to predict the upcoming events. Hence PCs receive a multiplexed climbing fiber input that merges complementary streams of information on the behavior, separable by the recipient PC because they are staggered in time.Akshay MarkandayJunya InouePeter W DickePeter ThierPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 9, p e3001400 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Akshay Markanday Junya Inoue Peter W Dicke Peter Thier Cerebellar complex spikes multiplex complementary behavioral information.
description	Purkinje cell (PC) discharge, the only output of cerebellar cortex, involves 2 types of action potentials, high-frequency simple spikes (SSs) and low-frequency complex spikes (CSs). While there is consensus that SSs convey information needed to optimize movement kinematics, the function of CSs, determined by the PC's climbing fiber input, remains controversial. While initially thought to be specialized in reporting information on motor error for the subsequent amendment of behavior, CSs seem to contribute to other aspects of motor behavior as well. When faced with the bewildering diversity of findings and views unraveled by highly specific tasks, one may wonder if there is just one true function with all the other attributions wrong? Or is the diversity of findings a reflection of distinct pools of PCs, each processing specific streams of information conveyed by climbing fibers? With these questions in mind, we recorded CSs from the monkey oculomotor vermis deploying a repetitive saccade task that entailed sizable motor errors as well as small amplitude saccades, correcting them. We demonstrate that, in addition to carrying error-related information, CSs carry information on the metrics of both primary and small corrective saccades in a time-specific manner, with changes in CS firing probability coupled with changes in CS duration. Furthermore, we also found CS activity that seemed to predict the upcoming events. Hence PCs receive a multiplexed climbing fiber input that merges complementary streams of information on the behavior, separable by the recipient PC because they are staggered in time.
format	article
author	Akshay Markanday Junya Inoue Peter W Dicke Peter Thier
author_facet	Akshay Markanday Junya Inoue Peter W Dicke Peter Thier
author_sort	Akshay Markanday
title	Cerebellar complex spikes multiplex complementary behavioral information.
title_short	Cerebellar complex spikes multiplex complementary behavioral information.
title_full	Cerebellar complex spikes multiplex complementary behavioral information.
title_fullStr	Cerebellar complex spikes multiplex complementary behavioral information.
title_full_unstemmed	Cerebellar complex spikes multiplex complementary behavioral information.
title_sort	cerebellar complex spikes multiplex complementary behavioral information.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f0041c9dc35f4c8aba57fe9cc6a5318f
work_keys_str_mv	AT akshaymarkanday cerebellarcomplexspikesmultiplexcomplementarybehavioralinformation AT junyainoue cerebellarcomplexspikesmultiplexcomplementarybehavioralinformation AT peterwdicke cerebellarcomplexspikesmultiplexcomplementarybehavioralinformation AT peterthier cerebellarcomplexspikesmultiplexcomplementarybehavioralinformation
_version_	1718375937569980416

Cerebellar complex spikes multiplex complementary behavioral information.

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