PP1A-mediated dephosphorylation positively regulates YAP2 activity.

PP1A-mediated dephosphorylation positively regulates YAP2 activity.

<h4>Background</h4>The Hippo/MST1 signaling pathway plays an important role in the regulation of cell proliferation and apoptosis. As a major downstream target of the Hippo/MST1 pathway, YAP2 (Yes-associated protein 2) functions as a transcriptional cofactor that has been implicated in m...

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Main Authors: Pei Wang, Yujie Bai, Bangrong Song, Yadong Wang, Dong Liu, Yongqiang Lai, Xiaolin Bi, Zengqiang Yuan
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/f0069f76a112453e8bda58db9a72e770
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