TIRADS effectiveness in cancer risk prognosis among patients with cystic and solid thyroid nodules

Aim. To analyse the effectiveness of TIRADS scale modified by Russ for prediction of thyroid cancer and comparison of diagnostic capabilities of the scale in patients with solid and cystic thyroid nodules. Material and Methods. Patients, who underwent surgery for thyroid nodules in period of 2015...

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Autores principales:	V.N. Marina, O.V. Lukavetskiy, V.I. Kolomiytsev
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2018
Materias:	cystic thyroid nodes, thyroid cancer, tirads Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f00f12058bf2488ea5368f223985d3b8
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spelling	oai:doaj.org-article:f00f12058bf2488ea5368f223985d3b82021-11-10T19:50:03ZTIRADS effectiveness in cancer risk prognosis among patients with cystic and solid thyroid nodules1029-42442415-330310.25040/aml2018.03.004https://doaj.org/article/f00f12058bf2488ea5368f223985d3b82018-09-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/90https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim. To analyse the effectiveness of TIRADS scale modified by Russ for prediction of thyroid cancer and comparison of diagnostic capabilities of the scale in patients with solid and cystic thyroid nodules. Material and Methods. Patients, who underwent surgery for thyroid nodules in period of 2015-2016 at the Department of Surgery No. 1 of the Lviv National Medical University were taken to research, and retrospective analysis was carried out. Stratification of thyroid cancer risk was performed by evaluation of ultrasonography findings according to the TIRADS scale. The obtained data were analysed for both solid and cystic thyroid nodules separately. Results and Discussion. In total, 1033 patients aged 17 to 82 years were operated for thyroid nodules. In 385 (37.3%) cases we failed to stratify by TIRADS due to lack of information in ultrasonographic description. Subsequent analysis was done over remaining 648 patients, among which 96 (14.8%) cases of cancer were proven. Patients were divided into 2 groups: Group I - "cystic nodules" - 164 (25.3%) patients; Group II - "solid nodules" - 484 (74.7%) patients. In group І thyroid cancer prevalence was 3.7%, while in group II it was 18.6%. The difference in thyroid cancer incidence had a significant statistical probability (c2=21.655; p <0.00001). There was a difference in the frequency of "papillary microcarcinoma" among cystic and solid nodules: 1.2% and 3.5% respectively. In the prediction of cancer in patients with cystic thyroid nodules, TIRADS scale demonstrated a high specificity of 93.0%, while the sensitivity was low - 16.7%. The TIRADS scale in assessing of cystic thyroid nodules showed a high overall diagnostic accuracy of 90.2%, but the level of positive predictive value for thyroid cancer among cystic nodules was low - 8.3%, especially when compared to solid nodules - 44.1%. Conclusions. TIRADS is an effective method in predicting thyroid cancer, especially among solid nodules. Cancer prevalence among cystic thyroid nodules is significantly lower compared to solid nodules: 3.7% vs. 18.6%. The low sensitivity of the TIRADS scale in patients with cystic thyroid nodules is 16.7%, and therefore cases with cystic nodules graded TIRADS 2-4a require precise follow up.V.N. MarinaO.V. LukavetskiyV.I. KolomiytsevDanylo Halytsky Lviv National Medical Universityarticlecystic thyroid nodes, thyroid cancer, tiradsMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 24, Iss 3, Pp 4-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	cystic thyroid nodes, thyroid cancer, tirads Medicine (General) R5-920
spellingShingle	cystic thyroid nodes, thyroid cancer, tirads Medicine (General) R5-920 V.N. Marina O.V. Lukavetskiy V.I. Kolomiytsev TIRADS effectiveness in cancer risk prognosis among patients with cystic and solid thyroid nodules
description	Aim. To analyse the effectiveness of TIRADS scale modified by Russ for prediction of thyroid cancer and comparison of diagnostic capabilities of the scale in patients with solid and cystic thyroid nodules. Material and Methods. Patients, who underwent surgery for thyroid nodules in period of 2015-2016 at the Department of Surgery No. 1 of the Lviv National Medical University were taken to research, and retrospective analysis was carried out. Stratification of thyroid cancer risk was performed by evaluation of ultrasonography findings according to the TIRADS scale. The obtained data were analysed for both solid and cystic thyroid nodules separately. Results and Discussion. In total, 1033 patients aged 17 to 82 years were operated for thyroid nodules. In 385 (37.3%) cases we failed to stratify by TIRADS due to lack of information in ultrasonographic description. Subsequent analysis was done over remaining 648 patients, among which 96 (14.8%) cases of cancer were proven. Patients were divided into 2 groups: Group I - "cystic nodules" - 164 (25.3%) patients; Group II - "solid nodules" - 484 (74.7%) patients. In group І thyroid cancer prevalence was 3.7%, while in group II it was 18.6%. The difference in thyroid cancer incidence had a significant statistical probability (c2=21.655; p <0.00001). There was a difference in the frequency of "papillary microcarcinoma" among cystic and solid nodules: 1.2% and 3.5% respectively. In the prediction of cancer in patients with cystic thyroid nodules, TIRADS scale demonstrated a high specificity of 93.0%, while the sensitivity was low - 16.7%. The TIRADS scale in assessing of cystic thyroid nodules showed a high overall diagnostic accuracy of 90.2%, but the level of positive predictive value for thyroid cancer among cystic nodules was low - 8.3%, especially when compared to solid nodules - 44.1%. Conclusions. TIRADS is an effective method in predicting thyroid cancer, especially among solid nodules. Cancer prevalence among cystic thyroid nodules is significantly lower compared to solid nodules: 3.7% vs. 18.6%. The low sensitivity of the TIRADS scale in patients with cystic thyroid nodules is 16.7%, and therefore cases with cystic nodules graded TIRADS 2-4a require precise follow up.
format	article
author	V.N. Marina O.V. Lukavetskiy V.I. Kolomiytsev
author_facet	V.N. Marina O.V. Lukavetskiy V.I. Kolomiytsev
author_sort	V.N. Marina
title	TIRADS effectiveness in cancer risk prognosis among patients with cystic and solid thyroid nodules
title_short	TIRADS effectiveness in cancer risk prognosis among patients with cystic and solid thyroid nodules
title_full	TIRADS effectiveness in cancer risk prognosis among patients with cystic and solid thyroid nodules
title_fullStr	TIRADS effectiveness in cancer risk prognosis among patients with cystic and solid thyroid nodules
title_full_unstemmed	TIRADS effectiveness in cancer risk prognosis among patients with cystic and solid thyroid nodules
title_sort	tirads effectiveness in cancer risk prognosis among patients with cystic and solid thyroid nodules
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2018
url	https://doaj.org/article/f00f12058bf2488ea5368f223985d3b8
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TIRADS effectiveness in cancer risk prognosis among patients with cystic and solid thyroid nodules

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