Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection
Mycobacteriosis, mostly resulting from Mycobacterium tuberculosis (MTb), nontuberculous mycobacteria (NTM), and Mycobacterium leprae (M. leprae), is the long-standing granulomatous disease that ravages several organs including skin, lung, and peripheral nerves, and it has a spectrum of clinical-path...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:f013561bbad04b798d7fa906bbf0a57f2021-11-09T06:58:31ZProgress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection1664-322410.3389/fimmu.2021.752657https://doaj.org/article/f013561bbad04b798d7fa906bbf0a57f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.752657/fullhttps://doaj.org/toc/1664-3224Mycobacteriosis, mostly resulting from Mycobacterium tuberculosis (MTb), nontuberculous mycobacteria (NTM), and Mycobacterium leprae (M. leprae), is the long-standing granulomatous disease that ravages several organs including skin, lung, and peripheral nerves, and it has a spectrum of clinical-pathologic features based on the interaction of bacilli and host immune response. Histiocytes in infectious granulomas mainly consist of infected and uninfected macrophages (Mφs), multinucleated giant cells (MGCs), epithelioid cells (ECs), and foam cells (FCs), which are commonly discovered in lesions in patients with mycobacteriosis. Granuloma Mφ polarization or reprogramming is the crucial appearance of the host immune response to pathogen aggression, which gets a command of endocellular microbe persistence. Herein, we recapitulate the current gaps and challenges during Mφ polarization and the different subpopulations of mycobacteriosis.Gai GeHaiqin JiangJingshu XiongWenyue ZhangYing ShiChenyue TaoHongsheng WangHongsheng WangHongsheng WangFrontiers Media S.A.articlemycobacteriosisgranulomamacrophagesmultinucleated giant cellsepithelioid cellsfoam cellsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
mycobacteriosis granuloma macrophages multinucleated giant cells epithelioid cells foam cells Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
mycobacteriosis granuloma macrophages multinucleated giant cells epithelioid cells foam cells Immunologic diseases. Allergy RC581-607 Gai Ge Haiqin Jiang Jingshu Xiong Wenyue Zhang Ying Shi Chenyue Tao Hongsheng Wang Hongsheng Wang Hongsheng Wang Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection |
| description |
Mycobacteriosis, mostly resulting from Mycobacterium tuberculosis (MTb), nontuberculous mycobacteria (NTM), and Mycobacterium leprae (M. leprae), is the long-standing granulomatous disease that ravages several organs including skin, lung, and peripheral nerves, and it has a spectrum of clinical-pathologic features based on the interaction of bacilli and host immune response. Histiocytes in infectious granulomas mainly consist of infected and uninfected macrophages (Mφs), multinucleated giant cells (MGCs), epithelioid cells (ECs), and foam cells (FCs), which are commonly discovered in lesions in patients with mycobacteriosis. Granuloma Mφ polarization or reprogramming is the crucial appearance of the host immune response to pathogen aggression, which gets a command of endocellular microbe persistence. Herein, we recapitulate the current gaps and challenges during Mφ polarization and the different subpopulations of mycobacteriosis. |
| format |
article |
| author |
Gai Ge Haiqin Jiang Jingshu Xiong Wenyue Zhang Ying Shi Chenyue Tao Hongsheng Wang Hongsheng Wang Hongsheng Wang |
| author_facet |
Gai Ge Haiqin Jiang Jingshu Xiong Wenyue Zhang Ying Shi Chenyue Tao Hongsheng Wang Hongsheng Wang Hongsheng Wang |
| author_sort |
Gai Ge |
| title |
Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection |
| title_short |
Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection |
| title_full |
Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection |
| title_fullStr |
Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection |
| title_full_unstemmed |
Progress of the Art of Macrophage Polarization and Different Subtypes in Mycobacterial Infection |
| title_sort |
progress of the art of macrophage polarization and different subtypes in mycobacterial infection |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/f013561bbad04b798d7fa906bbf0a57f |
| work_keys_str_mv |
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