Transcranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI

BackgroundTranscranial sonography (TCS) is a convenient tool for detecting certain brain diseases, such as brain tumors. Few studies have reported on the use of TCS in the area of Sella turcica. The accuracy and repeatability of Sella turcica with or without pituitary tumor is not clear.PurposeThis...

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Autores principales:	Lei He, Jinghan Zhang, Tengfei Yu, Yue Du, Xinyao Liu, Wen He
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ultrasonography Doppler transcranial MRI Sella turcica pituitary neoplasms Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/f0139e6c896d4836be927c3153106f97
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spelling	oai:doaj.org-article:f0139e6c896d4836be927c3153106f972021-12-03T13:31:43ZTranscranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI1664-239210.3389/fendo.2021.778839https://doaj.org/article/f0139e6c896d4836be927c3153106f972021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.778839/fullhttps://doaj.org/toc/1664-2392BackgroundTranscranial sonography (TCS) is a convenient tool for detecting certain brain diseases, such as brain tumors. Few studies have reported on the use of TCS in the area of Sella turcica. The accuracy and repeatability of Sella turcica with or without pituitary tumor is not clear.PurposeThis study aimed to investigate the feasibility and accuracy of TCS to measure the size of Sella turcica according to the measurement in MRI and determine its diagnostic performance in individuals with pituitary tumor.Materials and MethodsIn this cross-sectional comparative study, healthy volunteers and patients with pituitary tumor were enrolled for examination of TCS and MRI between October 2020 and July 2021. The transverse diameter (D1, cm) of Sella turcica and the volume of the pituitary tumor were measured by TCS and MRI, respectively, and compared by using Student’s t-test or Mann–Whitney test, using the receiver operating characteristic (ROC) curve to analyze the diagnostic value of D1 in TCS for pituitary tumor.ResultsA total of 75 healthy volunteers and 51 patients with pituitary tumor were evaluated. In healthy volunteers, the mean D1 was 1.30 ± 0.35 (range, 0.82–3.22) by TCS and 1.32 ± 0.29 (range, 0.94–3.02) by MRI (P = 0.054). In patients with pituitary tumor, the mean D1 was 2.0 ± 0.65 (range, 0.90–3.48) by TCS and 2.42 ± 1.0 (range, 0.80–4.70) by MRI (P = 0.000). The median measurement volume was 4.41 and 6.59 cm3 in TCS and MR, respectively (P = 0.000). The mean D1 was 1.31 ± 0.35 in healthy volunteers and 2.0 ± 0.65 cm in patients with pituitary tumor (P = 0.000). In the ROC curve analysis, the area under the curve was 0.836, and the optimal cutoff value (1.56) exhibited a sensitivity and specificity of 67.31 and 88.0%, respectively.ConclusionThe consistency between the two imaging technologies performed well in D1 measurement, while the volume of the pituitary tumor was smaller as assessed by TCS than by MRI. D1 in TCS had good diagnostic performance in pituitary tumor.Lei HeJinghan ZhangTengfei YuYue DuXinyao LiuWen HeWen HeFrontiers Media S.A.articleultrasonographyDopplertranscranialMRISella turcicapituitary neoplasmsDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ultrasonography Doppler transcranial MRI Sella turcica pituitary neoplasms Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	ultrasonography Doppler transcranial MRI Sella turcica pituitary neoplasms Diseases of the endocrine glands. Clinical endocrinology RC648-665 Lei He Jinghan Zhang Tengfei Yu Yue Du Xinyao Liu Wen He Wen He Transcranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI
description	BackgroundTranscranial sonography (TCS) is a convenient tool for detecting certain brain diseases, such as brain tumors. Few studies have reported on the use of TCS in the area of Sella turcica. The accuracy and repeatability of Sella turcica with or without pituitary tumor is not clear.PurposeThis study aimed to investigate the feasibility and accuracy of TCS to measure the size of Sella turcica according to the measurement in MRI and determine its diagnostic performance in individuals with pituitary tumor.Materials and MethodsIn this cross-sectional comparative study, healthy volunteers and patients with pituitary tumor were enrolled for examination of TCS and MRI between October 2020 and July 2021. The transverse diameter (D1, cm) of Sella turcica and the volume of the pituitary tumor were measured by TCS and MRI, respectively, and compared by using Student’s t-test or Mann–Whitney test, using the receiver operating characteristic (ROC) curve to analyze the diagnostic value of D1 in TCS for pituitary tumor.ResultsA total of 75 healthy volunteers and 51 patients with pituitary tumor were evaluated. In healthy volunteers, the mean D1 was 1.30 ± 0.35 (range, 0.82–3.22) by TCS and 1.32 ± 0.29 (range, 0.94–3.02) by MRI (P = 0.054). In patients with pituitary tumor, the mean D1 was 2.0 ± 0.65 (range, 0.90–3.48) by TCS and 2.42 ± 1.0 (range, 0.80–4.70) by MRI (P = 0.000). The median measurement volume was 4.41 and 6.59 cm3 in TCS and MR, respectively (P = 0.000). The mean D1 was 1.31 ± 0.35 in healthy volunteers and 2.0 ± 0.65 cm in patients with pituitary tumor (P = 0.000). In the ROC curve analysis, the area under the curve was 0.836, and the optimal cutoff value (1.56) exhibited a sensitivity and specificity of 67.31 and 88.0%, respectively.ConclusionThe consistency between the two imaging technologies performed well in D1 measurement, while the volume of the pituitary tumor was smaller as assessed by TCS than by MRI. D1 in TCS had good diagnostic performance in pituitary tumor.
format	article
author	Lei He Jinghan Zhang Tengfei Yu Yue Du Xinyao Liu Wen He Wen He
author_facet	Lei He Jinghan Zhang Tengfei Yu Yue Du Xinyao Liu Wen He Wen He
author_sort	Lei He
title	Transcranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI
title_short	Transcranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI
title_full	Transcranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI
title_fullStr	Transcranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI
title_full_unstemmed	Transcranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI
title_sort	transcranial sonography in the diagnosis of pituitary tumor—a direct comparison with mri
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f0139e6c896d4836be927c3153106f97
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Transcranial Sonography in the Diagnosis of Pituitary Tumor—A Direct Comparison With MRI

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