Basement membranes in obstructive pulmonary diseases

Increased and changed deposition of extracellular matrix proteins is a key feature of airway wall remodeling in obstructive pulmonary diseases, including asthma and chronic obstructive pulmonary disease. Studies have highlighted that the deposition of various basement membrane proteins in the lung t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bart G.J. Dekkers, Shehab I. Saad, Leah J. van Spelde, Janette K. Burgess
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Asthma Chronic obstructive pulmonary disease Laminin Collagen IV Airway remodeling Airway inflammation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f0148f3d358544b99f307cc0d8edf7ac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f0148f3d358544b99f307cc0d8edf7ac
record_format	dspace
spelling	oai:doaj.org-article:f0148f3d358544b99f307cc0d8edf7ac2021-11-26T04:38:51ZBasement membranes in obstructive pulmonary diseases2590-028510.1016/j.mbplus.2021.100092https://doaj.org/article/f0148f3d358544b99f307cc0d8edf7ac2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590028521000363https://doaj.org/toc/2590-0285Increased and changed deposition of extracellular matrix proteins is a key feature of airway wall remodeling in obstructive pulmonary diseases, including asthma and chronic obstructive pulmonary disease. Studies have highlighted that the deposition of various basement membrane proteins in the lung tissue is altered and that these changes reflect tissue compartment specificity. Inflammatory responses in both diseases may result in the deregulation of production and degradation of these proteins. In addition to their role in tissue development and integrity, emerging evidence indicates that basement membrane proteins also actively modulate cellular processes in obstructive airway diseases, contributing to disease development, progression and maintenance. In this review, we summarize the changes in basement membrane composition in airway remodeling in obstructive airway diseases and explore their potential application as innovative targets for treatment development.Bart G.J. DekkersShehab I. SaadLeah J. van SpeldeJanette K. BurgessElsevierarticleAsthmaChronic obstructive pulmonary diseaseLamininCollagen IVAirway remodelingAirway inflammationBiology (General)QH301-705.5ENMatrix Biology Plus, Vol 12, Iss , Pp 100092- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Asthma Chronic obstructive pulmonary disease Laminin Collagen IV Airway remodeling Airway inflammation Biology (General) QH301-705.5
spellingShingle	Asthma Chronic obstructive pulmonary disease Laminin Collagen IV Airway remodeling Airway inflammation Biology (General) QH301-705.5 Bart G.J. Dekkers Shehab I. Saad Leah J. van Spelde Janette K. Burgess Basement membranes in obstructive pulmonary diseases
description	Increased and changed deposition of extracellular matrix proteins is a key feature of airway wall remodeling in obstructive pulmonary diseases, including asthma and chronic obstructive pulmonary disease. Studies have highlighted that the deposition of various basement membrane proteins in the lung tissue is altered and that these changes reflect tissue compartment specificity. Inflammatory responses in both diseases may result in the deregulation of production and degradation of these proteins. In addition to their role in tissue development and integrity, emerging evidence indicates that basement membrane proteins also actively modulate cellular processes in obstructive airway diseases, contributing to disease development, progression and maintenance. In this review, we summarize the changes in basement membrane composition in airway remodeling in obstructive airway diseases and explore their potential application as innovative targets for treatment development.
format	article
author	Bart G.J. Dekkers Shehab I. Saad Leah J. van Spelde Janette K. Burgess
author_facet	Bart G.J. Dekkers Shehab I. Saad Leah J. van Spelde Janette K. Burgess
author_sort	Bart G.J. Dekkers
title	Basement membranes in obstructive pulmonary diseases
title_short	Basement membranes in obstructive pulmonary diseases
title_full	Basement membranes in obstructive pulmonary diseases
title_fullStr	Basement membranes in obstructive pulmonary diseases
title_full_unstemmed	Basement membranes in obstructive pulmonary diseases
title_sort	basement membranes in obstructive pulmonary diseases
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f0148f3d358544b99f307cc0d8edf7ac
work_keys_str_mv	AT bartgjdekkers basementmembranesinobstructivepulmonarydiseases AT shehabisaad basementmembranesinobstructivepulmonarydiseases AT leahjvanspelde basementmembranesinobstructivepulmonarydiseases AT janettekburgess basementmembranesinobstructivepulmonarydiseases
_version_	1718409876150943744

Basement membranes in obstructive pulmonary diseases

Ejemplares similares