Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature

Adenoid cystic carcinoma of the external auditory canal is very rare tumour. Its course is mainly indolent, and is characterised by intracranial extension, high rates of loco-regional relapse, and distant metastasis, which culminates in a slow detrimental disease course, eventually leading to death....

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Autores principales:	Nuria Mederos, Jeremy Jankovic, Ruth Gabriela Herrera Gomez, Vincent Dunet, Valerie Cristina
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	External auditory canal Adenoid cystic carcinoma Epirubicin Bevacizumab Case report Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f01acb1ee18c4000bb2e24190f868580
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spelling	oai:doaj.org-article:f01acb1ee18c4000bb2e24190f8685802021-11-28T04:38:51ZIntracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature2666-621910.1016/j.cpccr.2021.100130https://doaj.org/article/f01acb1ee18c4000bb2e24190f8685802021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666621921000788https://doaj.org/toc/2666-6219Adenoid cystic carcinoma of the external auditory canal is very rare tumour. Its course is mainly indolent, and is characterised by intracranial extension, high rates of loco-regional relapse, and distant metastasis, which culminates in a slow detrimental disease course, eventually leading to death. The main therapeutic modalities are local therapies such as surgery and/or radiotherapy. Systemic treatment has never achieved good clinical outcomes in this setting. Here, we describe the case report of a 50-year-old female, diagnosed with an adenoid cystic carcinoma of the right external auditory canal in 2003. The patient developed multiples recurrences, including an extensive intracerebral progression associated with radio necrosis, for which systemic therapy with bevacizumab and epirubicin was initiated. This achieved an intracerebral partial response with clinical benefit, allowing the rapid tapering of corticosteroid treatment. This case report highlights epirubicin in combination with bevacizumab as a therapeutic option for heavily treated patients with adenoid cystic carcinoma and intracranial involvement.Nuria MederosJeremy JankovicRuth Gabriela Herrera GomezVincent DunetValerie CristinaElsevierarticleExternal auditory canalAdenoid cystic carcinomaEpirubicinBevacizumabCase reportNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCurrent Problems in Cancer: Case Reports, Vol 4, Iss , Pp 100130- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	External auditory canal Adenoid cystic carcinoma Epirubicin Bevacizumab Case report Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	External auditory canal Adenoid cystic carcinoma Epirubicin Bevacizumab Case report Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Nuria Mederos Jeremy Jankovic Ruth Gabriela Herrera Gomez Vincent Dunet Valerie Cristina Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature
description	Adenoid cystic carcinoma of the external auditory canal is very rare tumour. Its course is mainly indolent, and is characterised by intracranial extension, high rates of loco-regional relapse, and distant metastasis, which culminates in a slow detrimental disease course, eventually leading to death. The main therapeutic modalities are local therapies such as surgery and/or radiotherapy. Systemic treatment has never achieved good clinical outcomes in this setting. Here, we describe the case report of a 50-year-old female, diagnosed with an adenoid cystic carcinoma of the right external auditory canal in 2003. The patient developed multiples recurrences, including an extensive intracerebral progression associated with radio necrosis, for which systemic therapy with bevacizumab and epirubicin was initiated. This achieved an intracerebral partial response with clinical benefit, allowing the rapid tapering of corticosteroid treatment. This case report highlights epirubicin in combination with bevacizumab as a therapeutic option for heavily treated patients with adenoid cystic carcinoma and intracranial involvement.
format	article
author	Nuria Mederos Jeremy Jankovic Ruth Gabriela Herrera Gomez Vincent Dunet Valerie Cristina
author_facet	Nuria Mederos Jeremy Jankovic Ruth Gabriela Herrera Gomez Vincent Dunet Valerie Cristina
author_sort	Nuria Mederos
title	Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature
title_short	Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature
title_full	Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature
title_fullStr	Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature
title_full_unstemmed	Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature
title_sort	intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: a case report and review of the literature
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f01acb1ee18c4000bb2e24190f868580
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Intracranial response to a combination of bevacizumab and epirubicin for an adenoid cystic carcinoma of the external auditory canal: A case report and review of the literature

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