Prognostic Stratification Based on HIF-1 Signaling for Evaluating Hypoxic Status and Immune Infiltration in Pancreatic Ductal Adenocarcinomas

Prognostic Stratification Based on HIF-1 Signaling for Evaluating Hypoxic Status and Immune Infiltration in Pancreatic Ductal Adenocarcinomas

Pancreatic ductal adenocarcinoma (PDAC) has a hypoxic and desmoplastic tumor microenvironment (TME), leading to treatment failure. We aimed to develop a prognostic classifier to evaluate hypoxia status and hypoxia-related molecular characteristics of PDAC. In this study, we classified PDAC into thre...

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Bibliographic Details
Main Authors: Hongkai Zhuang, Shujie Wang, Bo Chen, Zedan Zhang, Zuyi Ma, Zhenchong Li, Chunsheng Liu, Zixuan Zhou, Yuanfeng Gong, Shanzhou Huang, Baohua Hou, Yajin Chen, Chuanzhao Zhang
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
PDAC
HIF-1
hypoxia
ICB
immunosuppression
immune infiltration
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/f01bb09807914c998608fb4ce4f0fc3a
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https://doaj.org/article/f01bb09807914c998608fb4ce4f0fc3a

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