Relation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study

Background: Iron deficiency anemia [IDA] is a very common medical condition affecting primary school-age children, with several unfavorable consequences. There are some reports pointing to a possible effect of IDA on thyroid gland function.Aim of the work: To assess thyroid function in primary schoo...

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Autores principales:	Gamal Gamal, mohamed zannoun, Saad Mohamed, Gamal Mohamed
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	thyroid primary school age egyptian iron deficiency anemia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f01e5a3dd26449e2ac02b0012b0c1604
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spelling	oai:doaj.org-article:f01e5a3dd26449e2ac02b0012b0c16042021-12-02T19:36:37ZRelation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study2636-41742682-378010.21608/ijma.2021.83720.1336https://doaj.org/article/f01e5a3dd26449e2ac02b0012b0c16042021-10-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_197607_f0bacaa7dd61765bacf1180561fb25de.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Iron deficiency anemia [IDA] is a very common medical condition affecting primary school-age children, with several unfavorable consequences. There are some reports pointing to a possible effect of IDA on thyroid gland function.Aim of the work: To assess thyroid function in primary school age children in Damietta Governorate, Egypt with iron deficiency anemia and to investigate potential related risk factors.Patients and Methods: A controlled cross-sectional study included 100 primary school age children [age: 6-12 years]; 50 children with iron deficiency anemia [case group], and 50 healthy age- and sex-matched children [control group]. Complete blood count, serum iron, serum ferritin and thyroid hormone profile [thyroid stimulating hormone [TSH], free triiodothyronine [FT3] and free thyroxine [FT4] were analyzed for all children.Results: In the case group, compared to the control group, there was a significantly higher TSH level [2.77±1.30 vs. 2.10±1.11; P=0.006] and lower FT3 [3.22±0.82 vs. 3.61±0.69; P=0.011]. The frequency of hypothyroid status [both overt and subclinical] was elevated in the case group [24% vs. 6%; P=0.02]. There was a significant negative correlation between TSH with both serum iron [P=0.019] and ferritin [P=0.009].Conclusion: Iron deficiency anemia, especially when serum ferritin and iron are very low, in primary school children is associated with liability to get subclinical hypothyroidism.Gamal Gamalmohamed zannounSaad MohamedGamal MohamedAl-Azhar University, Faculty of Medicine (Damietta)articlethyroidprimary school ageegyptianiron deficiencyanemiaMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 4, Pp 1855-1861 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid primary school age egyptian iron deficiency anemia Medicine (General) R5-920
spellingShingle	thyroid primary school age egyptian iron deficiency anemia Medicine (General) R5-920 Gamal Gamal mohamed zannoun Saad Mohamed Gamal Mohamed Relation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study
description	Background: Iron deficiency anemia [IDA] is a very common medical condition affecting primary school-age children, with several unfavorable consequences. There are some reports pointing to a possible effect of IDA on thyroid gland function.Aim of the work: To assess thyroid function in primary school age children in Damietta Governorate, Egypt with iron deficiency anemia and to investigate potential related risk factors.Patients and Methods: A controlled cross-sectional study included 100 primary school age children [age: 6-12 years]; 50 children with iron deficiency anemia [case group], and 50 healthy age- and sex-matched children [control group]. Complete blood count, serum iron, serum ferritin and thyroid hormone profile [thyroid stimulating hormone [TSH], free triiodothyronine [FT3] and free thyroxine [FT4] were analyzed for all children.Results: In the case group, compared to the control group, there was a significantly higher TSH level [2.77±1.30 vs. 2.10±1.11; P=0.006] and lower FT3 [3.22±0.82 vs. 3.61±0.69; P=0.011]. The frequency of hypothyroid status [both overt and subclinical] was elevated in the case group [24% vs. 6%; P=0.02]. There was a significant negative correlation between TSH with both serum iron [P=0.019] and ferritin [P=0.009].Conclusion: Iron deficiency anemia, especially when serum ferritin and iron are very low, in primary school children is associated with liability to get subclinical hypothyroidism.
format	article
author	Gamal Gamal mohamed zannoun Saad Mohamed Gamal Mohamed
author_facet	Gamal Gamal mohamed zannoun Saad Mohamed Gamal Mohamed
author_sort	Gamal Gamal
title	Relation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study
title_short	Relation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study
title_full	Relation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study
title_fullStr	Relation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study
title_full_unstemmed	Relation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study
title_sort	relation between thyroid function and iron deficiency anemia in primary school-age children: a controlled cross-sectional study
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/f01e5a3dd26449e2ac02b0012b0c1604
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Relation between Thyroid Function and Iron Deficiency Anemia in Primary School-Age Children: A Controlled Cross-Sectional Study

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