Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density

Combining non-invasive brain stimulation (NIBS) with resting-state functional magnetic resonance imaging (rs-fMRI) is a promising approach to characterize and potentially optimize the brain networks subtending cognition that changes as a function of age. However, whether multifocal NIBS approaches a...

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Autores principales:	Kilian Abellaneda-Pérez, Lídia Vaqué-Alcázar, Ruben Perellón-Alfonso, Cristina Solé-Padullés, Núria Bargalló, Ricardo Salvador, Giulio Ruffini, Michael A. Nitsche, Alvaro Pascual-Leone, David Bartrés-Faz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aging electric current density multifocal transcranial direct current stimulation resting-state functional magnetic resonance imaging non-invasive brain stimulation (NIBS) electric modeling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f01fe5b7a97d40d69857dd386c99b907
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spelling	oai:doaj.org-article:f01fe5b7a97d40d69857dd386c99b9072021-12-01T07:59:49ZMultifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density1663-436510.3389/fnagi.2021.725013https://doaj.org/article/f01fe5b7a97d40d69857dd386c99b9072021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.725013/fullhttps://doaj.org/toc/1663-4365Combining non-invasive brain stimulation (NIBS) with resting-state functional magnetic resonance imaging (rs-fMRI) is a promising approach to characterize and potentially optimize the brain networks subtending cognition that changes as a function of age. However, whether multifocal NIBS approaches are able to modulate rs-fMRI brain dynamics in aged populations, and if these NIBS-induced changes are consistent with the simulated electric current distribution on the brain remains largely unknown. In the present investigation, thirty-one cognitively healthy older adults underwent two different multifocal real transcranial direct current stimulation (tDCS) conditions (C1 and C2) and a sham condition in a crossover design during a rs-fMRI acquisition. The real tDCS conditions were designed to electrically induce two distinct complex neural patterns, either targeting generalized frontoparietal cortical overactivity (C1) or a detachment between the frontal areas and the posteromedial cortex (C2). Data revealed that the two tDCS conditions modulated rs-fMRI differently. C1 increased the coactivation of multiple functional couplings as compared to sham, while a smaller number of connections increased in C1 as compared to C2. At the group level, C1-induced changes were topographically consistent with the calculated electric current density distribution. At the individual level, the extent of tDCS-induced rs-fMRI modulation in C1 was related with the magnitude of the simulated electric current density estimates. These results highlight that multifocal tDCS procedures can effectively change rs-fMRI neural functioning in advancing age, being the induced modulation consistent with the spatial distribution of the simulated electric current on the brain. Moreover, our data supports that individually tailoring NIBS-based interventions grounded on subject-specific structural data might be crucial to increase tDCS potential in future studies amongst older adults.Kilian Abellaneda-PérezKilian Abellaneda-PérezLídia Vaqué-AlcázarLídia Vaqué-AlcázarRuben Perellón-AlfonsoRuben Perellón-AlfonsoCristina Solé-PadullésCristina Solé-PadullésNúria BargallóNúria BargallóRicardo SalvadorRicardo SalvadorGiulio RuffiniGiulio RuffiniMichael A. NitscheMichael A. NitscheAlvaro Pascual-LeoneAlvaro Pascual-LeoneAlvaro Pascual-LeoneDavid Bartrés-FazDavid Bartrés-FazDavid Bartrés-FazFrontiers Media S.A.articleagingelectric current densitymultifocal transcranial direct current stimulationresting-state functional magnetic resonance imagingnon-invasive brain stimulation (NIBS)electric modelingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging electric current density multifocal transcranial direct current stimulation resting-state functional magnetic resonance imaging non-invasive brain stimulation (NIBS) electric modeling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	aging electric current density multifocal transcranial direct current stimulation resting-state functional magnetic resonance imaging non-invasive brain stimulation (NIBS) electric modeling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Kilian Abellaneda-Pérez Kilian Abellaneda-Pérez Lídia Vaqué-Alcázar Lídia Vaqué-Alcázar Ruben Perellón-Alfonso Ruben Perellón-Alfonso Cristina Solé-Padullés Cristina Solé-Padullés Núria Bargalló Núria Bargalló Ricardo Salvador Ricardo Salvador Giulio Ruffini Giulio Ruffini Michael A. Nitsche Michael A. Nitsche Alvaro Pascual-Leone Alvaro Pascual-Leone Alvaro Pascual-Leone David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density
description	Combining non-invasive brain stimulation (NIBS) with resting-state functional magnetic resonance imaging (rs-fMRI) is a promising approach to characterize and potentially optimize the brain networks subtending cognition that changes as a function of age. However, whether multifocal NIBS approaches are able to modulate rs-fMRI brain dynamics in aged populations, and if these NIBS-induced changes are consistent with the simulated electric current distribution on the brain remains largely unknown. In the present investigation, thirty-one cognitively healthy older adults underwent two different multifocal real transcranial direct current stimulation (tDCS) conditions (C1 and C2) and a sham condition in a crossover design during a rs-fMRI acquisition. The real tDCS conditions were designed to electrically induce two distinct complex neural patterns, either targeting generalized frontoparietal cortical overactivity (C1) or a detachment between the frontal areas and the posteromedial cortex (C2). Data revealed that the two tDCS conditions modulated rs-fMRI differently. C1 increased the coactivation of multiple functional couplings as compared to sham, while a smaller number of connections increased in C1 as compared to C2. At the group level, C1-induced changes were topographically consistent with the calculated electric current density distribution. At the individual level, the extent of tDCS-induced rs-fMRI modulation in C1 was related with the magnitude of the simulated electric current density estimates. These results highlight that multifocal tDCS procedures can effectively change rs-fMRI neural functioning in advancing age, being the induced modulation consistent with the spatial distribution of the simulated electric current on the brain. Moreover, our data supports that individually tailoring NIBS-based interventions grounded on subject-specific structural data might be crucial to increase tDCS potential in future studies amongst older adults.
format	article
author	Kilian Abellaneda-Pérez Kilian Abellaneda-Pérez Lídia Vaqué-Alcázar Lídia Vaqué-Alcázar Ruben Perellón-Alfonso Ruben Perellón-Alfonso Cristina Solé-Padullés Cristina Solé-Padullés Núria Bargalló Núria Bargalló Ricardo Salvador Ricardo Salvador Giulio Ruffini Giulio Ruffini Michael A. Nitsche Michael A. Nitsche Alvaro Pascual-Leone Alvaro Pascual-Leone Alvaro Pascual-Leone David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz
author_facet	Kilian Abellaneda-Pérez Kilian Abellaneda-Pérez Lídia Vaqué-Alcázar Lídia Vaqué-Alcázar Ruben Perellón-Alfonso Ruben Perellón-Alfonso Cristina Solé-Padullés Cristina Solé-Padullés Núria Bargalló Núria Bargalló Ricardo Salvador Ricardo Salvador Giulio Ruffini Giulio Ruffini Michael A. Nitsche Michael A. Nitsche Alvaro Pascual-Leone Alvaro Pascual-Leone Alvaro Pascual-Leone David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz
author_sort	Kilian Abellaneda-Pérez
title	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density
title_short	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density
title_full	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density
title_fullStr	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density
title_full_unstemmed	Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density
title_sort	multifocal transcranial direct current stimulation modulates resting-state functional connectivity in older adults depending on the induced current density
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f01fe5b7a97d40d69857dd386c99b907
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Multifocal Transcranial Direct Current Stimulation Modulates Resting-State Functional Connectivity in Older Adults Depending on the Induced Current Density

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