Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols

Lady Serrano Mujica,1 Alessandra Bridi,1,2 Ricardo Della Méa,1 Vitor Braga Rissi,1 Naiara Guarda,3 Rafael Noal Moresco,3 Melissa Orlandin Premaor,4 Alfredo Quites Antoniazzi,1 Paulo Bayard Dias Gonçalves,1 Fabio Vasconcellos Comim1,4 1Laboratory of Biotechnology and Animal Repr...

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Autores principales:	Serrano Mujica L, Bridi A, Della Méa R, Rissi VB, Guarda N, Moresco RN, Premaor MO, Antoniazzi AQ, Gonçalves PBD, Comim FV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	animal models of PCOS oxidative stress prenatal postnatal Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f0215b21362b4447874f27d3c01d3187
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spelling	oai:doaj.org-article:f0215b21362b4447874f27d3c01d31872021-12-02T01:27:02ZOxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols1178-7031https://doaj.org/article/f0215b21362b4447874f27d3c01d31872018-05-01T00:00:00Zhttps://www.dovepress.com/oxidative-stress-and-metabolic-markers-in-pre--and-postnatal-polycysti-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Lady Serrano Mujica,1 Alessandra Bridi,1,2 Ricardo Della Méa,1 Vitor Braga Rissi,1 Naiara Guarda,3 Rafael Noal Moresco,3 Melissa Orlandin Premaor,4 Alfredo Quites Antoniazzi,1 Paulo Bayard Dias Gonçalves,1 Fabio Vasconcellos Comim1,4 1Laboratory of Biotechnology and Animal Reproduction, BioRep, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, 2Department of Veterinary Medicine, University of São Paulo, São Paulo, 3Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, 4Department of Clinical Medicine, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil Background: Several studies have described an enhanced inflammatory status and oxidative stress balance disruption in women with polycystic ovary syndrome (PCOS). However, there is scarce information about redox markers in the blood of androgenized animal models. Here, we evaluated the serum/plasma oxidative stress marker and metabolic parameter characteristics of prenatal (PreN) and postnatal (PostN) androgenized rat models of PCOS. Materials and methods: For PreN androgenization (n=8), 2.5 mg of testosterone propionate was subcutaneously administered to dams at embryonic days 16, 17, and 18, whereas PostN androgenization (n=7) was accomplished by subcutaneously injecting 1.25 mg of testosterone propionate to animals at PostN day 5. A unique control group (n=8) was constituted for comparison. Results: Our results indicate that PostN group rats exhibited particular modifications in the oxidative stress marker, an increased plasma ferric-reducing ability of plasma, and an increased antioxidant capacity reflected by higher albumin serum levels. PostN animals also presented increased total cholesterol and triglyceride–glucose levels, suggesting severe metabolic disarrangement. Conclusion: Study findings indicate that changes in oxidative stress could be promoted by testosterone propionate exposure after birth, which is likely associated with anovulation and/or lipid disarrangement. Keywords: animal models of PCOS, oxidative stress, prenatal, postnatalSerrano Mujica LBridi ADella Méa RRissi VBGuarda NMoresco RNPremaor MOAntoniazzi AQGonçalves PBDComim FVDove Medical Pressarticleanimal models of PCOSoxidative stressprenatalpostnatalPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 11, Pp 193-202 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	animal models of PCOS oxidative stress prenatal postnatal Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	animal models of PCOS oxidative stress prenatal postnatal Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Serrano Mujica L Bridi A Della Méa R Rissi VB Guarda N Moresco RN Premaor MO Antoniazzi AQ Gonçalves PBD Comim FV Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
description	Lady Serrano Mujica,1 Alessandra Bridi,1,2 Ricardo Della Méa,1 Vitor Braga Rissi,1 Naiara Guarda,3 Rafael Noal Moresco,3 Melissa Orlandin Premaor,4 Alfredo Quites Antoniazzi,1 Paulo Bayard Dias Gonçalves,1 Fabio Vasconcellos Comim1,4 1Laboratory of Biotechnology and Animal Reproduction, BioRep, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, 2Department of Veterinary Medicine, University of São Paulo, São Paulo, 3Laboratory of Clinical Biochemistry, Department of Clinical and Toxicological Analysis, 4Department of Clinical Medicine, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil Background: Several studies have described an enhanced inflammatory status and oxidative stress balance disruption in women with polycystic ovary syndrome (PCOS). However, there is scarce information about redox markers in the blood of androgenized animal models. Here, we evaluated the serum/plasma oxidative stress marker and metabolic parameter characteristics of prenatal (PreN) and postnatal (PostN) androgenized rat models of PCOS. Materials and methods: For PreN androgenization (n=8), 2.5 mg of testosterone propionate was subcutaneously administered to dams at embryonic days 16, 17, and 18, whereas PostN androgenization (n=7) was accomplished by subcutaneously injecting 1.25 mg of testosterone propionate to animals at PostN day 5. A unique control group (n=8) was constituted for comparison. Results: Our results indicate that PostN group rats exhibited particular modifications in the oxidative stress marker, an increased plasma ferric-reducing ability of plasma, and an increased antioxidant capacity reflected by higher albumin serum levels. PostN animals also presented increased total cholesterol and triglyceride–glucose levels, suggesting severe metabolic disarrangement. Conclusion: Study findings indicate that changes in oxidative stress could be promoted by testosterone propionate exposure after birth, which is likely associated with anovulation and/or lipid disarrangement. Keywords: animal models of PCOS, oxidative stress, prenatal, postnatal
format	article
author	Serrano Mujica L Bridi A Della Méa R Rissi VB Guarda N Moresco RN Premaor MO Antoniazzi AQ Gonçalves PBD Comim FV
author_facet	Serrano Mujica L Bridi A Della Méa R Rissi VB Guarda N Moresco RN Premaor MO Antoniazzi AQ Gonçalves PBD Comim FV
author_sort	Serrano Mujica L
title	Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title_short	Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title_full	Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title_fullStr	Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title_full_unstemmed	Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
title_sort	oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f0215b21362b4447874f27d3c01d3187
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Oxidative stress and metabolic markers in pre- and postnatal polycystic ovary syndrome rat protocols

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