Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures.

<h4>Objective</h4>Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50-60%. Cancer stem cells (CSC) are capable of surviving...

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Autores principales: Mehdi Shakibaei, Constanze Buhrmann, Patricia Kraehe, Parviz Shayan, Cora Lueders, Ajay Goel
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/f02170a457eb4387a51c9ad50162b35c
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