Evaluation of cognitive impairment in patients with major depressive disorder in remission

Abstract Background Cognitive symptoms are one of the core symptoms of depressive disorders with a bearing effect on functional outcomes. Cognitive symptoms, including poor concentration and difficulty making decisions, are one of the DSM-IV diagnostic criteria for major depressive disorder. This st...

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Autores principales:	Mustafa Ali, Magda Fahmy, Wafaa Haggag, Ashraf El-Tantawy, Haydy Hassan
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Major depressive disorder Cognitive impairments Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/f0217634bdc54d0abbbbae05abc49dc7
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spelling	oai:doaj.org-article:f0217634bdc54d0abbbbae05abc49dc72021-11-21T12:05:28ZEvaluation of cognitive impairment in patients with major depressive disorder in remission10.1186/s43045-021-00149-x2090-5416https://doaj.org/article/f0217634bdc54d0abbbbae05abc49dc72021-11-01T00:00:00Zhttps://doi.org/10.1186/s43045-021-00149-xhttps://doaj.org/toc/2090-5416Abstract Background Cognitive symptoms are one of the core symptoms of depressive disorders with a bearing effect on functional outcomes. Cognitive symptoms, including poor concentration and difficulty making decisions, are one of the DSM-IV diagnostic criteria for major depressive disorder. This study was designed to evaluate cognitive deficits in a sample of adult patients with major depressive disorder (MDD) in remission. A cross-sectional study was done on 60 patients fulfilling the diagnostic criteria of MDD in remission state. In addition, 60 normal subjects with matched age, sex, and educational level were compared with the patients group. Participants in both patients and control groups were subjected to clinical assessment using Mini-International Neuropsychiatric Interview plus (MINI-plus), assessment of cognitive functions using Wechsler Memory Scale-Revised (WMS-R) short form, and Wisconsin Card Sorting Test (WCST). Results There were statistically significant differences between patients and control groups regarding cognitive function. The patients group scored less in visual memory, verbal memory, attention/concentration, and psychomotor speed. They also performed poorly regarding executive functions. But there was no statistically significant difference between the patients and control groups regarding sustained attention and visuospatial function. No significant correlations did exist between age at onset of MDD and the duration of illness with different domains of cognitive function except for figural memory of WMS-R and categories completed of Wisconsin card sorting test. Conclusion Patients with MDD in remission experienced deficits in several cognitive functions when compared to matched control subjects. The cognitive functions do not reach normal levels of performance, particularly in visual memory and executive functioning with remission of depressive symptoms.Mustafa AliMagda FahmyWafaa HaggagAshraf El-TantawyHaydy HassanSpringerOpenarticleMajor depressive disorderCognitive impairmentsPsychiatryRC435-571ENMiddle East Current Psychiatry, Vol 28, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Major depressive disorder Cognitive impairments Psychiatry RC435-571
spellingShingle	Major depressive disorder Cognitive impairments Psychiatry RC435-571 Mustafa Ali Magda Fahmy Wafaa Haggag Ashraf El-Tantawy Haydy Hassan Evaluation of cognitive impairment in patients with major depressive disorder in remission
description	Abstract Background Cognitive symptoms are one of the core symptoms of depressive disorders with a bearing effect on functional outcomes. Cognitive symptoms, including poor concentration and difficulty making decisions, are one of the DSM-IV diagnostic criteria for major depressive disorder. This study was designed to evaluate cognitive deficits in a sample of adult patients with major depressive disorder (MDD) in remission. A cross-sectional study was done on 60 patients fulfilling the diagnostic criteria of MDD in remission state. In addition, 60 normal subjects with matched age, sex, and educational level were compared with the patients group. Participants in both patients and control groups were subjected to clinical assessment using Mini-International Neuropsychiatric Interview plus (MINI-plus), assessment of cognitive functions using Wechsler Memory Scale-Revised (WMS-R) short form, and Wisconsin Card Sorting Test (WCST). Results There were statistically significant differences between patients and control groups regarding cognitive function. The patients group scored less in visual memory, verbal memory, attention/concentration, and psychomotor speed. They also performed poorly regarding executive functions. But there was no statistically significant difference between the patients and control groups regarding sustained attention and visuospatial function. No significant correlations did exist between age at onset of MDD and the duration of illness with different domains of cognitive function except for figural memory of WMS-R and categories completed of Wisconsin card sorting test. Conclusion Patients with MDD in remission experienced deficits in several cognitive functions when compared to matched control subjects. The cognitive functions do not reach normal levels of performance, particularly in visual memory and executive functioning with remission of depressive symptoms.
format	article
author	Mustafa Ali Magda Fahmy Wafaa Haggag Ashraf El-Tantawy Haydy Hassan
author_facet	Mustafa Ali Magda Fahmy Wafaa Haggag Ashraf El-Tantawy Haydy Hassan
author_sort	Mustafa Ali
title	Evaluation of cognitive impairment in patients with major depressive disorder in remission
title_short	Evaluation of cognitive impairment in patients with major depressive disorder in remission
title_full	Evaluation of cognitive impairment in patients with major depressive disorder in remission
title_fullStr	Evaluation of cognitive impairment in patients with major depressive disorder in remission
title_full_unstemmed	Evaluation of cognitive impairment in patients with major depressive disorder in remission
title_sort	evaluation of cognitive impairment in patients with major depressive disorder in remission
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/f0217634bdc54d0abbbbae05abc49dc7
work_keys_str_mv	AT mustafaali evaluationofcognitiveimpairmentinpatientswithmajordepressivedisorderinremission AT magdafahmy evaluationofcognitiveimpairmentinpatientswithmajordepressivedisorderinremission AT wafaahaggag evaluationofcognitiveimpairmentinpatientswithmajordepressivedisorderinremission AT ashrafeltantawy evaluationofcognitiveimpairmentinpatientswithmajordepressivedisorderinremission AT haydyhassan evaluationofcognitiveimpairmentinpatientswithmajordepressivedisorderinremission
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Evaluation of cognitive impairment in patients with major depressive disorder in remission

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