Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

Little is known about the effects of methamphetamine (Meth) and buprenorphine (Bup) on memory and learning in rats. The aim of this investigation was to examine the impact of Meth and Bup on memory and learning. Fourteen male Wistar rats weighing 250–300 g were assigned to four groups: Sham, Meth, B...

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Autores principales:	Farshid Etaee, Arezoo Rezvani-Kamran, Somayeh Komaki, Masoumeh Asadbegi, Nafiseh Faraji, Safoura Raoufi, Mohammad Taheri, Masoumeh Kourosh-Arami, Alireza Komaki
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	methamphetamine buprenorphine learning memory interaction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f022c897b76745d595298e3b8abc56b5
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spelling	oai:doaj.org-article:f022c897b76745d595298e3b8abc56b52021-11-30T13:57:01ZEffects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats1662-515310.3389/fnbeh.2021.748563https://doaj.org/article/f022c897b76745d595298e3b8abc56b52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.748563/fullhttps://doaj.org/toc/1662-5153Little is known about the effects of methamphetamine (Meth) and buprenorphine (Bup) on memory and learning in rats. The aim of this investigation was to examine the impact of Meth and Bup on memory and learning. Fourteen male Wistar rats weighing 250–300 g were assigned to four groups: Sham, Meth, Bup, and Meth + Bup and were treated for 1 week. Spatial learning and memory, avoidance learning, and locomotion were assessed using the Morris water maze, passive avoidance learning, and open field tests, respectively. Meth and Bup impaired spatial learning and memory in rats. Co-administration of Meth + Bup did not increase the time spent in the target quadrant compared to Meth alone in the MWM. The Bup and Meh + Bup groups were found with an increase in step-through latency (STLr) and a decrease in the time spent in the dark compartment (TDC). Meth and Bup had no effects on locomotor activity in the open field test. Bup showed a beneficial effect on aversive memory. Since Bup demonstrates fewer side effects than other opioid drugs, it may be preferable for the treatment of avoidance memory deficits in patients with Meth addiction.Farshid EtaeeFarshid EtaeeArezoo Rezvani-KamranSomayeh KomakiMasoumeh AsadbegiNafiseh FarajiSafoura RaoufiMohammad TaheriMasoumeh Kourosh-AramiAlireza KomakiFrontiers Media S.A.articlemethamphetaminebuprenorphinelearningmemoryinteractionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	methamphetamine buprenorphine learning memory interaction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	methamphetamine buprenorphine learning memory interaction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Farshid Etaee Farshid Etaee Arezoo Rezvani-Kamran Somayeh Komaki Masoumeh Asadbegi Nafiseh Faraji Safoura Raoufi Mohammad Taheri Masoumeh Kourosh-Arami Alireza Komaki Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats
description	Little is known about the effects of methamphetamine (Meth) and buprenorphine (Bup) on memory and learning in rats. The aim of this investigation was to examine the impact of Meth and Bup on memory and learning. Fourteen male Wistar rats weighing 250–300 g were assigned to four groups: Sham, Meth, Bup, and Meth + Bup and were treated for 1 week. Spatial learning and memory, avoidance learning, and locomotion were assessed using the Morris water maze, passive avoidance learning, and open field tests, respectively. Meth and Bup impaired spatial learning and memory in rats. Co-administration of Meth + Bup did not increase the time spent in the target quadrant compared to Meth alone in the MWM. The Bup and Meh + Bup groups were found with an increase in step-through latency (STLr) and a decrease in the time spent in the dark compartment (TDC). Meth and Bup had no effects on locomotor activity in the open field test. Bup showed a beneficial effect on aversive memory. Since Bup demonstrates fewer side effects than other opioid drugs, it may be preferable for the treatment of avoidance memory deficits in patients with Meth addiction.
format	article
author	Farshid Etaee Farshid Etaee Arezoo Rezvani-Kamran Somayeh Komaki Masoumeh Asadbegi Nafiseh Faraji Safoura Raoufi Mohammad Taheri Masoumeh Kourosh-Arami Alireza Komaki
author_facet	Farshid Etaee Farshid Etaee Arezoo Rezvani-Kamran Somayeh Komaki Masoumeh Asadbegi Nafiseh Faraji Safoura Raoufi Mohammad Taheri Masoumeh Kourosh-Arami Alireza Komaki
author_sort	Farshid Etaee
title	Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats
title_short	Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats
title_full	Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats
title_fullStr	Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats
title_full_unstemmed	Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats
title_sort	effects of buprenorphine on the memory and learning deficit induced by methamphetamine administration in male rats
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f022c897b76745d595298e3b8abc56b5
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Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

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