Site-specific identification and quantitation of endogenous SUMO modifications under native conditions

SUMOylation is post-translational modification implicated in several biological pathways. Here the authors describe an approach for the global profiling of SUMO attachment sites under native conditions that also allows the parallel determination of SUMO and Ub attachments.

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Detalles Bibliográficos
Autores principales: Ryan J. Lumpkin, Hongbo Gu, Yiying Zhu, Marilyn Leonard, Alla S. Ahmad, Karl R. Clauser, Jesse G. Meyer, Eric J. Bennett, Elizabeth A. Komives
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/f02473b4764a4f27b6f2fc77fb366869
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Sumario:SUMOylation is post-translational modification implicated in several biological pathways. Here the authors describe an approach for the global profiling of SUMO attachment sites under native conditions that also allows the parallel determination of SUMO and Ub attachments.