AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway

DNA double strand breaks can be repaired by homology-independent or homology-directed mechanisms. The choice between these pathways is a key event for genomic stability maintenance. Here the authors identify and characterize AUNIP, as a factor involved in tilting the balance towards homology repair.

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Autores principales:	Jiangman Lou, Hongxia Chen, Jinhua Han, Hanqing He, Michael S. Y. Huen, Xin-hua Feng, Ting Liu, Jun Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f024789b884d464d8ae7a4ddd5ce5459
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spelling	oai:doaj.org-article:f024789b884d464d8ae7a4ddd5ce54592021-12-02T17:06:25ZAUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway10.1038/s41467-017-01151-w2041-1723https://doaj.org/article/f024789b884d464d8ae7a4ddd5ce54592017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01151-whttps://doaj.org/toc/2041-1723DNA double strand breaks can be repaired by homology-independent or homology-directed mechanisms. The choice between these pathways is a key event for genomic stability maintenance. Here the authors identify and characterize AUNIP, as a factor involved in tilting the balance towards homology repair.Jiangman LouHongxia ChenJinhua HanHanqing HeMichael S. Y. HuenXin-hua FengTing LiuJun HuangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiangman Lou Hongxia Chen Jinhua Han Hanqing He Michael S. Y. Huen Xin-hua Feng Ting Liu Jun Huang AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway
description	DNA double strand breaks can be repaired by homology-independent or homology-directed mechanisms. The choice between these pathways is a key event for genomic stability maintenance. Here the authors identify and characterize AUNIP, as a factor involved in tilting the balance towards homology repair.
format	article
author	Jiangman Lou Hongxia Chen Jinhua Han Hanqing He Michael S. Y. Huen Xin-hua Feng Ting Liu Jun Huang
author_facet	Jiangman Lou Hongxia Chen Jinhua Han Hanqing He Michael S. Y. Huen Xin-hua Feng Ting Liu Jun Huang
author_sort	Jiangman Lou
title	AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway
title_short	AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway
title_full	AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway
title_fullStr	AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway
title_full_unstemmed	AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway
title_sort	aunip/c1orf135 directs dna double-strand breaks towards the homologous recombination repair pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f024789b884d464d8ae7a4ddd5ce5459
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AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway

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