AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway

AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway

DNA double strand breaks can be repaired by homology-independent or homology-directed mechanisms. The choice between these pathways is a key event for genomic stability maintenance. Here the authors identify and characterize AUNIP, as a factor involved in tilting the balance towards homology repair.

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Autores principales: Jiangman Lou, Hongxia Chen, Jinhua Han, Hanqing He, Michael S. Y. Huen, Xin-hua Feng, Ting Liu, Jun Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/f024789b884d464d8ae7a4ddd5ce5459
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