Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate

Asymmetric functionalization of N–H bonds constitutes an important but less developed class of reactions. Here, the authors report the asymmetric direct N-propargylation of indoles and carbazoles with a lithium SPINOL phosphate as the chiral catalyst and shed light on the reaction mechanism.

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Autores principales:	Yingcheng Wang, Sheng Wang, Wenyu Shan, Zhihui Shao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f0297b5c324646a1b9b6c1c80de3145b
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spelling	oai:doaj.org-article:f0297b5c324646a1b9b6c1c80de3145b2021-12-02T16:49:30ZDirect asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate10.1038/s41467-019-13886-92041-1723https://doaj.org/article/f0297b5c324646a1b9b6c1c80de3145b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13886-9https://doaj.org/toc/2041-1723Asymmetric functionalization of N–H bonds constitutes an important but less developed class of reactions. Here, the authors report the asymmetric direct N-propargylation of indoles and carbazoles with a lithium SPINOL phosphate as the chiral catalyst and shed light on the reaction mechanism.Yingcheng WangSheng WangWenyu ShanZhihui ShaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingcheng Wang Sheng Wang Wenyu Shan Zhihui Shao Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate
description	Asymmetric functionalization of N–H bonds constitutes an important but less developed class of reactions. Here, the authors report the asymmetric direct N-propargylation of indoles and carbazoles with a lithium SPINOL phosphate as the chiral catalyst and shed light on the reaction mechanism.
format	article
author	Yingcheng Wang Sheng Wang Wenyu Shan Zhihui Shao
author_facet	Yingcheng Wang Sheng Wang Wenyu Shan Zhihui Shao
author_sort	Yingcheng Wang
title	Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate
title_short	Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate
title_full	Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate
title_fullStr	Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate
title_full_unstemmed	Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate
title_sort	direct asymmetric n-propargylation of indoles and carbazoles catalyzed by lithium spinol phosphate
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f0297b5c324646a1b9b6c1c80de3145b
work_keys_str_mv	AT yingchengwang directasymmetricnpropargylationofindolesandcarbazolescatalyzedbylithiumspinolphosphate AT shengwang directasymmetricnpropargylationofindolesandcarbazolescatalyzedbylithiumspinolphosphate AT wenyushan directasymmetricnpropargylationofindolesandcarbazolescatalyzedbylithiumspinolphosphate AT zhihuishao directasymmetricnpropargylationofindolesandcarbazolescatalyzedbylithiumspinolphosphate
_version_	1718383311885172736

Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate

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