Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression
Hongliang Zhou, 1 Lingling Hua, 1 Haiteng Jiang, 2 Zongpeng Dai, 2 Yinglin Han, 1 Pinhua Lin, 1 Haofei Wang, 1 Qing Lu, 2, 3 Zhijian Yao 1, 4 1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; 2School of Bio...
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Dove Medical Press
2020
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oai:doaj.org-article:f02dc896c00844739239af5260ef553e2021-12-02T05:43:55ZAutonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression1178-2021https://doaj.org/article/f02dc896c00844739239af5260ef553e2020-01-01T00:00:00Zhttps://www.dovepress.com/autonomic-nervous-system-is-related-to-inhibitory-and-control-function-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hongliang Zhou, 1 Lingling Hua, 1 Haiteng Jiang, 2 Zongpeng Dai, 2 Yinglin Han, 1 Pinhua Lin, 1 Haofei Wang, 1 Qing Lu, 2, 3 Zhijian Yao 1, 4 1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; 2School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, People’s Republic of China; 3Child Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing 210096, People’s Republic of China; 4Nanjing Brain Hospital, Medical School of Nanjing University, Nanjing 210093, People’s Republic of ChinaCorrespondence: Zhijian YaoDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of ChinaTel +8625 8229600Fax +8625 82296000Email zjyao@njmu.edu.cnQing LuSchool of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, People’s Republic of ChinaTel/Fax +8625 83792349Email luq@seu.edu.cnObjective: To investigate the mechanism of interactions between autonomic nervous system (ANS) and cognitive function in Major depression (MD) with Magnetoencephalography (MEG) measurements.Methods: Participants with MD (n = 20), and Health controls (HCs, n = 18) were completed MEG measurements during the performance of a go/no-go task. Heart rate variability (HRV) indices (SDANN, and RMSSD) were derived from the raw MEG data. The correlation analysis of the HRV and functional connectivities in different brain regions was conducted by Pearson’s r in two groups.Results: The go/no-go task performances of HCs were better than MD patients; HRV indices were lower in the MD group. Under the no-go task, a brain MEG functional connectivity analysis based on the seed regions of the orbitofrontal cortex (OFC) displayed increased functional inter-region connectivity networks of OFC in MD group. HRV indices were correlated with different functional inter-region connectivity networks of OFC in two groups, respectively.Conclusion: ANS is related to inhibitory and control function through functional inter-region connectivity networks of OFC in MD. These findings have important implications for the understanding pathophysiology of MD, and MEG may provide an image-guided tool for interventions.Keywords: major depression, magnetoencephalography, heart rate variability, functional connectivity, the orbitofrontal cortexZhou HHua LJiang HDai ZHan YLin PWang HLu QYao ZDove Medical Pressarticlemajor depressionmagnetoencephalographyheart rate variabilityfunctional connectivitythe orbit-frontal cortexNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 235-247 (2020) |
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major depression magnetoencephalography heart rate variability functional connectivity the orbit-frontal cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
major depression magnetoencephalography heart rate variability functional connectivity the orbit-frontal cortex Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhou H Hua L Jiang H Dai Z Han Y Lin P Wang H Lu Q Yao Z Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression |
| description |
Hongliang Zhou, 1 Lingling Hua, 1 Haiteng Jiang, 2 Zongpeng Dai, 2 Yinglin Han, 1 Pinhua Lin, 1 Haofei Wang, 1 Qing Lu, 2, 3 Zhijian Yao 1, 4 1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; 2School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, People’s Republic of China; 3Child Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing 210096, People’s Republic of China; 4Nanjing Brain Hospital, Medical School of Nanjing University, Nanjing 210093, People’s Republic of ChinaCorrespondence: Zhijian YaoDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of ChinaTel +8625 8229600Fax +8625 82296000Email zjyao@njmu.edu.cnQing LuSchool of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, People’s Republic of ChinaTel/Fax +8625 83792349Email luq@seu.edu.cnObjective: To investigate the mechanism of interactions between autonomic nervous system (ANS) and cognitive function in Major depression (MD) with Magnetoencephalography (MEG) measurements.Methods: Participants with MD (n = 20), and Health controls (HCs, n = 18) were completed MEG measurements during the performance of a go/no-go task. Heart rate variability (HRV) indices (SDANN, and RMSSD) were derived from the raw MEG data. The correlation analysis of the HRV and functional connectivities in different brain regions was conducted by Pearson’s r in two groups.Results: The go/no-go task performances of HCs were better than MD patients; HRV indices were lower in the MD group. Under the no-go task, a brain MEG functional connectivity analysis based on the seed regions of the orbitofrontal cortex (OFC) displayed increased functional inter-region connectivity networks of OFC in MD group. HRV indices were correlated with different functional inter-region connectivity networks of OFC in two groups, respectively.Conclusion: ANS is related to inhibitory and control function through functional inter-region connectivity networks of OFC in MD. These findings have important implications for the understanding pathophysiology of MD, and MEG may provide an image-guided tool for interventions.Keywords: major depression, magnetoencephalography, heart rate variability, functional connectivity, the orbitofrontal cortex |
| format |
article |
| author |
Zhou H Hua L Jiang H Dai Z Han Y Lin P Wang H Lu Q Yao Z |
| author_facet |
Zhou H Hua L Jiang H Dai Z Han Y Lin P Wang H Lu Q Yao Z |
| author_sort |
Zhou H |
| title |
Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression |
| title_short |
Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression |
| title_full |
Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression |
| title_fullStr |
Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression |
| title_full_unstemmed |
Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression |
| title_sort |
autonomic nervous system is related to inhibitory and control function through functional inter-region connectivities of ofc in major depression |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/f02dc896c00844739239af5260ef553e |
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