Changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study

Abstract Few studies have investigated the impact of a change in metabolic syndrome (MetS) components on clinical renal outcomes in the general population. Using nationally representative data from the Korean National Health Insurance System, 13,310,924 subjects who underwent two health examinations...

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Autores principales:	Eun Sil Koh, Kyung Do Han, Mee Kyoung Kim, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Oak-Kee Hong, Hyuk-Sang Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f030cc927423483388f4184722dbfc1f
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spelling	oai:doaj.org-article:f030cc927423483388f4184722dbfc1f2021-12-02T13:51:15ZChanges in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study10.1038/s41598-021-81396-02045-2322https://doaj.org/article/f030cc927423483388f4184722dbfc1f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81396-0https://doaj.org/toc/2045-2322Abstract Few studies have investigated the impact of a change in metabolic syndrome (MetS) components on clinical renal outcomes in the general population. Using nationally representative data from the Korean National Health Insurance System, 13,310,924 subjects who underwent two health examinations over 2 years and were free from end-stage renal disease (ESRD) from 2009 to 2012 were followed to the end of 2016. The subjects were divided into four groups according to the change in MetS components between the two visits over 2 years: no MetS (–/–), post-MetS (–/+), pre-MetS (+/–), and both MetS (+/+). After a median follow up of 5.11 years, 18,582 incident ESRD cases were identified. In the multivariate adjusted model, the hazard ratio (HR) and 95% confidence interval (CI) for the development of ESRD in the both-MetS (+/+) group compared with the no-MetS (–/–) group was 5.65 (95% CI, 5.42–5.89), which was independent of age, sex, and baseline estimated glomerular filtration rate. Additionally, the HR for the pre-MetS (+/–) group versus the no-MetS (–/–) group was 2.28 (2.15–2.42). In subgroup analysis according to renal function, the impact of a change in MetS on the incidence of ESRD was more pronounced in individuals with advanced renal dysfunction. Subjects with resolved MetS components had a decreased risk of ESRD, but not as low as those that never had MetS components. This provides evidence supporting the strategy of modulating MetS in the general population to prevent the development of ESRD.Eun Sil KohKyung Do HanMee Kyoung KimEun Sook KimMin-Kyung LeeGa Eun NamOak-Kee HongHyuk-Sang KwonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eun Sil Koh Kyung Do Han Mee Kyoung Kim Eun Sook Kim Min-Kyung Lee Ga Eun Nam Oak-Kee Hong Hyuk-Sang Kwon Changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study
description	Abstract Few studies have investigated the impact of a change in metabolic syndrome (MetS) components on clinical renal outcomes in the general population. Using nationally representative data from the Korean National Health Insurance System, 13,310,924 subjects who underwent two health examinations over 2 years and were free from end-stage renal disease (ESRD) from 2009 to 2012 were followed to the end of 2016. The subjects were divided into four groups according to the change in MetS components between the two visits over 2 years: no MetS (–/–), post-MetS (–/+), pre-MetS (+/–), and both MetS (+/+). After a median follow up of 5.11 years, 18,582 incident ESRD cases were identified. In the multivariate adjusted model, the hazard ratio (HR) and 95% confidence interval (CI) for the development of ESRD in the both-MetS (+/+) group compared with the no-MetS (–/–) group was 5.65 (95% CI, 5.42–5.89), which was independent of age, sex, and baseline estimated glomerular filtration rate. Additionally, the HR for the pre-MetS (+/–) group versus the no-MetS (–/–) group was 2.28 (2.15–2.42). In subgroup analysis according to renal function, the impact of a change in MetS on the incidence of ESRD was more pronounced in individuals with advanced renal dysfunction. Subjects with resolved MetS components had a decreased risk of ESRD, but not as low as those that never had MetS components. This provides evidence supporting the strategy of modulating MetS in the general population to prevent the development of ESRD.
format	article
author	Eun Sil Koh Kyung Do Han Mee Kyoung Kim Eun Sook Kim Min-Kyung Lee Ga Eun Nam Oak-Kee Hong Hyuk-Sang Kwon
author_facet	Eun Sil Koh Kyung Do Han Mee Kyoung Kim Eun Sook Kim Min-Kyung Lee Ga Eun Nam Oak-Kee Hong Hyuk-Sang Kwon
author_sort	Eun Sil Koh
title	Changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study
title_short	Changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study
title_full	Changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study
title_fullStr	Changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study
title_full_unstemmed	Changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study
title_sort	changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f030cc927423483388f4184722dbfc1f
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Changes in metabolic syndrome status affect the incidence of end-stage renal disease in the general population: a nationwide cohort study

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