Experimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research

Dry eye disease (DED) is one of the major ophthalmological healthcare challenges worldwide. DED is a multifactorial disease characterized by a loss of homeostasis of the tear film, and its main pathogenesis is chronic ocular surface inflammation related with various cellular and molecular signaling...

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Autores principales:	Md. Mahbubur Rahman, Dong Hyun Kim, Chul-Kyu Park, Yong Ho Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dry eye pathophysiology in vitro models in vivo models therapeutic protocol measured parameters Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f032adf477a14f8cbaef80b7e7fe4f5d
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spelling	oai:doaj.org-article:f032adf477a14f8cbaef80b7e7fe4f5d2021-11-25T17:53:39ZExperimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research10.3390/ijms2222121021422-00671661-6596https://doaj.org/article/f032adf477a14f8cbaef80b7e7fe4f5d2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12102https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Dry eye disease (DED) is one of the major ophthalmological healthcare challenges worldwide. DED is a multifactorial disease characterized by a loss of homeostasis of the tear film, and its main pathogenesis is chronic ocular surface inflammation related with various cellular and molecular signaling cascades. The animal model is a reliable and effective tool for understanding the various pathological mechanisms and molecular cascades in DED. Considerable experimental research has focused on developing new strategies for the prevention and treatment of DED. Several experimental models of DED have been developed, and different animal species such as rats, mice, rabbits, dogs, and primates have been used for these models. Although the basic mechanisms of DED in animals are nearly identical to those in humans, proper knowledge about the induction of animal models is necessary to obtain better and more reliable results. Various experimental models (in vitro and in vivo DED models) were briefly discussed in this review, along with pathologic features, analytical approaches, and common measurements, which will help investigators to use the appropriate cell lines, animal, methods, and evaluation parameters depending on their study design.Md. Mahbubur RahmanDong Hyun KimChul-Kyu ParkYong Ho KimMDPI AGarticledry eyepathophysiologyin vitro modelsin vivo modelstherapeutic protocolmeasured parametersBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12102, p 12102 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye pathophysiology in vitro models in vivo models therapeutic protocol measured parameters Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	dry eye pathophysiology in vitro models in vivo models therapeutic protocol measured parameters Biology (General) QH301-705.5 Chemistry QD1-999 Md. Mahbubur Rahman Dong Hyun Kim Chul-Kyu Park Yong Ho Kim Experimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research
description	Dry eye disease (DED) is one of the major ophthalmological healthcare challenges worldwide. DED is a multifactorial disease characterized by a loss of homeostasis of the tear film, and its main pathogenesis is chronic ocular surface inflammation related with various cellular and molecular signaling cascades. The animal model is a reliable and effective tool for understanding the various pathological mechanisms and molecular cascades in DED. Considerable experimental research has focused on developing new strategies for the prevention and treatment of DED. Several experimental models of DED have been developed, and different animal species such as rats, mice, rabbits, dogs, and primates have been used for these models. Although the basic mechanisms of DED in animals are nearly identical to those in humans, proper knowledge about the induction of animal models is necessary to obtain better and more reliable results. Various experimental models (in vitro and in vivo DED models) were briefly discussed in this review, along with pathologic features, analytical approaches, and common measurements, which will help investigators to use the appropriate cell lines, animal, methods, and evaluation parameters depending on their study design.
format	article
author	Md. Mahbubur Rahman Dong Hyun Kim Chul-Kyu Park Yong Ho Kim
author_facet	Md. Mahbubur Rahman Dong Hyun Kim Chul-Kyu Park Yong Ho Kim
author_sort	Md. Mahbubur Rahman
title	Experimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research
title_short	Experimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research
title_full	Experimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research
title_fullStr	Experimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research
title_full_unstemmed	Experimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research
title_sort	experimental models, induction protocols, and measured parameters in dry eye disease: focusing on practical implications for experimental research
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f032adf477a14f8cbaef80b7e7fe4f5d
work_keys_str_mv	AT mdmahbuburrahman experimentalmodelsinductionprotocolsandmeasuredparametersindryeyediseasefocusingonpracticalimplicationsforexperimentalresearch AT donghyunkim experimentalmodelsinductionprotocolsandmeasuredparametersindryeyediseasefocusingonpracticalimplicationsforexperimentalresearch AT chulkyupark experimentalmodelsinductionprotocolsandmeasuredparametersindryeyediseasefocusingonpracticalimplicationsforexperimentalresearch AT yonghokim experimentalmodelsinductionprotocolsandmeasuredparametersindryeyediseasefocusingonpracticalimplicationsforexperimentalresearch
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Experimental Models, Induction Protocols, and Measured Parameters in Dry Eye Disease: Focusing on Practical Implications for Experimental Research

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