Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction

Francisco José Muñoz Negrete,1 Hans G Lemij,2 Carl Erb3 1Ophthalmology Service, Hospital Ramón y Cajal, Madrid, Spain; 2Glaucoma Service, Rotterdam Eye Hospital, Rotterdam, the Netherlands; 3Augenklinik Wittenbergplatz, Berlin, Germany Abstract: Patient satisfactio...

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Autores principales:	Muñoz Negrete FJ, Lemij HG, Erb C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Prostaglandins analogs glaucoma therapy preservative patient satisfaction tolerability persistence tear substitutes. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f034b2d2b534446d965f06d8d8a2ff5e
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spelling	oai:doaj.org-article:f034b2d2b534446d965f06d8d8a2ff5e2021-12-02T06:36:56ZSwitching to preservative-free latanoprost: impact on tolerability and patient satisfaction1177-5483https://doaj.org/article/f034b2d2b534446d965f06d8d8a2ff5e2017-03-01T00:00:00Zhttps://www.dovepress.com/switching-to-preservative-free-latanoprost-impact-on-tolerability-and--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Francisco José Muñoz Negrete,1 Hans G Lemij,2 Carl Erb3 1Ophthalmology Service, Hospital Ramón y Cajal, Madrid, Spain; 2Glaucoma Service, Rotterdam Eye Hospital, Rotterdam, the Netherlands; 3Augenklinik Wittenbergplatz, Berlin, Germany Abstract: Patient satisfaction with glaucoma treatment has been poorly studied to date. Because glaucoma is a chronic condition in which the therapeutic response is dependent on adherence to treatment, patient acceptability is an important factor in achieving satisfactory outcomes. This multicenter, international (Belgium, the Netherlands, and Spain), epidemiological convenience sample survey among patients commencing treatment with preservative-free latanoprost collected data on patient satisfaction with particular regard to tolerability. A total of 1,541 patients were recruited who were predominantly elderly (74% were over 60 years of age) and female (61%). Most of the patients had previously received preserved topical glaucoma medication (69%), 6.7% had previously received preservative-free medication, whereas 24% had not previously been treated for glaucoma. The great majority of patients (>95%) were satisfied with the preservative-free latanoprost treatment. Among the patients who had previously received preserved medication, 73% of patients found preservative-free latanoprost to be better tolerated and 89% found it at least as easy to use as their prior treatment. Patient satisfaction (determined by a 0–100 mm visual analog scale) was improved by 47% on a switch from preserved treatment to preservative-free latanoprost. Intraocular pressure was similar in patients who had previously received preserved (18.3 mmHg), preservative-free (17.8 mmHg) glaucoma medication or who were naïve to treatment (20.3 mmHg). Preservative-free latanoprost provided effective reduction of intraocular pressure with better tolerability and patient satisfaction than preserved glaucoma medication. This tolerability profile can be expected to improve adherence to treatment in glaucoma patients. Keywords: prostaglandins analogs, glaucoma therapy, preservative, patient satisfaction, tolerability, persistence, tear substitutesMuñoz Negrete FJLemij HGErb CDove Medical PressarticleProstaglandins analogsglaucoma therapypreservativepatient satisfactiontolerabilitypersistencetear substitutes.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 557-566 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Prostaglandins analogs glaucoma therapy preservative patient satisfaction tolerability persistence tear substitutes. Ophthalmology RE1-994
spellingShingle	Prostaglandins analogs glaucoma therapy preservative patient satisfaction tolerability persistence tear substitutes. Ophthalmology RE1-994 Muñoz Negrete FJ Lemij HG Erb C Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction
description	Francisco José Muñoz Negrete,1 Hans G Lemij,2 Carl Erb3 1Ophthalmology Service, Hospital Ramón y Cajal, Madrid, Spain; 2Glaucoma Service, Rotterdam Eye Hospital, Rotterdam, the Netherlands; 3Augenklinik Wittenbergplatz, Berlin, Germany Abstract: Patient satisfaction with glaucoma treatment has been poorly studied to date. Because glaucoma is a chronic condition in which the therapeutic response is dependent on adherence to treatment, patient acceptability is an important factor in achieving satisfactory outcomes. This multicenter, international (Belgium, the Netherlands, and Spain), epidemiological convenience sample survey among patients commencing treatment with preservative-free latanoprost collected data on patient satisfaction with particular regard to tolerability. A total of 1,541 patients were recruited who were predominantly elderly (74% were over 60 years of age) and female (61%). Most of the patients had previously received preserved topical glaucoma medication (69%), 6.7% had previously received preservative-free medication, whereas 24% had not previously been treated for glaucoma. The great majority of patients (>95%) were satisfied with the preservative-free latanoprost treatment. Among the patients who had previously received preserved medication, 73% of patients found preservative-free latanoprost to be better tolerated and 89% found it at least as easy to use as their prior treatment. Patient satisfaction (determined by a 0–100 mm visual analog scale) was improved by 47% on a switch from preserved treatment to preservative-free latanoprost. Intraocular pressure was similar in patients who had previously received preserved (18.3 mmHg), preservative-free (17.8 mmHg) glaucoma medication or who were naïve to treatment (20.3 mmHg). Preservative-free latanoprost provided effective reduction of intraocular pressure with better tolerability and patient satisfaction than preserved glaucoma medication. This tolerability profile can be expected to improve adherence to treatment in glaucoma patients. Keywords: prostaglandins analogs, glaucoma therapy, preservative, patient satisfaction, tolerability, persistence, tear substitutes
format	article
author	Muñoz Negrete FJ Lemij HG Erb C
author_facet	Muñoz Negrete FJ Lemij HG Erb C
author_sort	Muñoz Negrete FJ
title	Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction
title_short	Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction
title_full	Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction
title_fullStr	Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction
title_full_unstemmed	Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction
title_sort	switching to preservative-free latanoprost: impact on tolerability and patient satisfaction
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/f034b2d2b534446d965f06d8d8a2ff5e
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_version_	1718399847433764864

Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction

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