Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice

Summary: GLP-1 analogs are a class of glucose-lowering agents with multiple benefits in diabetes, but its role in adipose tissues remains to be elucidated. The aim of this study was to determine the action of recombinant human GLP-1 (rhGLP-1) Beinaglutide (BN) in the insulin sensitivity and lipid me...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Feng Zhang, Zhinan Chen, Dan Wu, Le Tian, Qing Chen, Yuqing Ye, Wei Chen, Xiaoxing Wu, Peng Wu, Weilan Yuan, Yan Qiu, Zhiguang Zhou, Zhiqiang Du, Fang Hu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Molecular physiology Cell biology Lipidomics Science Q
Acceso en línea:	https://doaj.org/article/f03646cf5f70481c8c26d7ae93a36146
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f03646cf5f70481c8c26d7ae93a36146
record_format	dspace
spelling	oai:doaj.org-article:f03646cf5f70481c8c26d7ae93a361462021-11-18T04:51:12ZRecombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice2589-004210.1016/j.isci.2021.103382https://doaj.org/article/f03646cf5f70481c8c26d7ae93a361462021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013535https://doaj.org/toc/2589-0042Summary: GLP-1 analogs are a class of glucose-lowering agents with multiple benefits in diabetes, but its role in adipose tissues remains to be elucidated. The aim of this study was to determine the action of recombinant human GLP-1 (rhGLP-1) Beinaglutide (BN) in the insulin sensitivity and lipid metabolism of adipose tissues. We have shown that, after BN injection, obese mice displayed lower body weight, fat mass, and plasma lipid levels. In addition, BN promoted the insulin sensitivity in the white adipose tissues. Furthermore, we have found that the BN treatment caused significant changes in content and composition of different lipid classes, including glycerolipids, glycerophospholipids, and sphingolipids, as well as expression of genes in lipid metabolic pathways in the adipose tissues. Taken together, our data demonstrate that BN could resist HFD-induced obesity by targeting the composition of major lipid classes and the expression of genes in lipid metabolism of adipose tissues.Feng ZhangZhinan ChenDan WuLe TianQing ChenYuqing YeWei ChenXiaoxing WuPeng WuWeilan YuanYan QiuZhiguang ZhouZhiqiang DuFang HuElsevierarticleMolecular physiologyCell biologyLipidomicsScienceQENiScience, Vol 24, Iss 12, Pp 103382- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Molecular physiology Cell biology Lipidomics Science Q
spellingShingle	Molecular physiology Cell biology Lipidomics Science Q Feng Zhang Zhinan Chen Dan Wu Le Tian Qing Chen Yuqing Ye Wei Chen Xiaoxing Wu Peng Wu Weilan Yuan Yan Qiu Zhiguang Zhou Zhiqiang Du Fang Hu Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
description	Summary: GLP-1 analogs are a class of glucose-lowering agents with multiple benefits in diabetes, but its role in adipose tissues remains to be elucidated. The aim of this study was to determine the action of recombinant human GLP-1 (rhGLP-1) Beinaglutide (BN) in the insulin sensitivity and lipid metabolism of adipose tissues. We have shown that, after BN injection, obese mice displayed lower body weight, fat mass, and plasma lipid levels. In addition, BN promoted the insulin sensitivity in the white adipose tissues. Furthermore, we have found that the BN treatment caused significant changes in content and composition of different lipid classes, including glycerolipids, glycerophospholipids, and sphingolipids, as well as expression of genes in lipid metabolic pathways in the adipose tissues. Taken together, our data demonstrate that BN could resist HFD-induced obesity by targeting the composition of major lipid classes and the expression of genes in lipid metabolism of adipose tissues.
format	article
author	Feng Zhang Zhinan Chen Dan Wu Le Tian Qing Chen Yuqing Ye Wei Chen Xiaoxing Wu Peng Wu Weilan Yuan Yan Qiu Zhiguang Zhou Zhiqiang Du Fang Hu
author_facet	Feng Zhang Zhinan Chen Dan Wu Le Tian Qing Chen Yuqing Ye Wei Chen Xiaoxing Wu Peng Wu Weilan Yuan Yan Qiu Zhiguang Zhou Zhiqiang Du Fang Hu
author_sort	Feng Zhang
title	Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title_short	Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title_full	Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title_fullStr	Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title_full_unstemmed	Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
title_sort	recombinant human glp-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f03646cf5f70481c8c26d7ae93a36146
work_keys_str_mv	AT fengzhang recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT zhinanchen recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT danwu recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT letian recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT qingchen recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT yuqingye recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT weichen recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT xiaoxingwu recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT pengwu recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT weilanyuan recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT yanqiu recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT zhiguangzhou recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT zhiqiangdu recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice AT fanghu recombinanthumanglp1beinaglutideregulateslipidmetabolismofadiposetissuesindietinducedobesemice
_version_	1718425010801999872

Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice

Ejemplares similares