Virtual Screening for Potential Phytobioactives as Therapeutic Leads to Inhibit NQO1 for Selective Anticancer Therapy

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Virtual Screening for Potential Phytobioactives as Therapeutic Leads to Inhibit NQO1 for Selective Anticancer Therapy

NAD(P)H:quinone acceptor oxidoreductase-1 (NQO1) is a ubiquitous flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory two-electron reductions of quinones, quinonimines, nitroaromatics, and azo dyes. NQO1 is a multifunctional antioxidant enzyme whose expression and deletion are...

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Auteurs principaux:	Bhargav Shreevatsa, Chandan Dharmashekara, Vikas Halasumane Swamy, Meghana V. Gowda, Raghu Ram Achar, Vivek Hamse Kameshwar, Rajesh Kumar Thimmulappa, Asad Syed, Abdallah M. Elgorban, Salim S. Al-Rejaie, Joaquín Ortega-Castro, Juan Frau, Norma Flores-Holguín, Chandan Shivamallu, Shiva Prasad Kollur, Daniel Glossman-Mitnik
Format:	article
Langue:	EN
Publié:	MDPI AG 2021
Sujets:	NQO1 virtual screening molecular docking Nrf2 detoxification phytobiactives Organic chemistry QD241-441
Accès en ligne:	https://doaj.org/article/f039d1eae82d4a3b8bc5c8c39db5e75f
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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