Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro

Breast cancer is the most common cancer in women worldwide. The antiproliferative activities of protopanaxatiol (PPT) and ginsenoside Rh2 was measured by evaluating the inhibition of MDA-MB-231 human breast cancer cell proliferation. The two-way combination of PPT and Rh2 was conducted. In the two-w...

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Autores principales:	Guixing Ren, Caie Wu, Cong Teng, Yang Yao
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	ppt rh2 synergy breast cancer antiproliferative activity Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f03bb78800bc48eea793c23dc83a0131
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spelling	oai:doaj.org-article:f03bb78800bc48eea793c23dc83a01312021-11-26T11:19:46ZSynergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro0954-01051465-344310.1080/09540105.2018.1490700https://doaj.org/article/f03bb78800bc48eea793c23dc83a01312018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1490700https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Breast cancer is the most common cancer in women worldwide. The antiproliferative activities of protopanaxatiol (PPT) and ginsenoside Rh2 was measured by evaluating the inhibition of MDA-MB-231 human breast cancer cell proliferation. The two-way combination of PPT and Rh2 was conducted. In the two-way combination, the EC50 values of PPT and Rh2 were 2.3- and 2.2-fold lower, respectively, than those of PPT and Rh2 alone. The combination index (CI) values were 0.55 ± 0.09, 0.65 ± 0.10, 0.79 ± 0.12, and 0.91 ± 0.14 at 50% and 95% inhibition rates. Combined PPT and Rh2 also increased the inhibition of cell invasion and migration compared with individual compounds tested in cell lines. Intracellular signalling array analysis demonstrated that phosphorylated BAD, p53, and p38 proteins were increased. The results indicate that combined PPT and Rh2 exhibits a synergistic effect in MDA-MB-231 cell proliferation.Guixing RenCaie WuCong TengYang YaoTaylor & Francis Grouparticlepptrh2synergybreast cancerantiproliferative activityAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 953-963 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ppt rh2 synergy breast cancer antiproliferative activity Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	ppt rh2 synergy breast cancer antiproliferative activity Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Guixing Ren Caie Wu Cong Teng Yang Yao Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro
description	Breast cancer is the most common cancer in women worldwide. The antiproliferative activities of protopanaxatiol (PPT) and ginsenoside Rh2 was measured by evaluating the inhibition of MDA-MB-231 human breast cancer cell proliferation. The two-way combination of PPT and Rh2 was conducted. In the two-way combination, the EC50 values of PPT and Rh2 were 2.3- and 2.2-fold lower, respectively, than those of PPT and Rh2 alone. The combination index (CI) values were 0.55 ± 0.09, 0.65 ± 0.10, 0.79 ± 0.12, and 0.91 ± 0.14 at 50% and 95% inhibition rates. Combined PPT and Rh2 also increased the inhibition of cell invasion and migration compared with individual compounds tested in cell lines. Intracellular signalling array analysis demonstrated that phosphorylated BAD, p53, and p38 proteins were increased. The results indicate that combined PPT and Rh2 exhibits a synergistic effect in MDA-MB-231 cell proliferation.
format	article
author	Guixing Ren Caie Wu Cong Teng Yang Yao
author_facet	Guixing Ren Caie Wu Cong Teng Yang Yao
author_sort	Guixing Ren
title	Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro
title_short	Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro
title_full	Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro
title_fullStr	Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro
title_full_unstemmed	Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro
title_sort	synergistic effect of combined protopanaxatiol and ginsenoside rh2 on antiproliferative activity in mda-mb-231 human breast cancer cells in vitro
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/f03bb78800bc48eea793c23dc83a0131
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Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro

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