Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker

Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker

Post-translational protein modifications can affect lifespan and aging but age-dependent ubiquitylation changes have not yet been systematically characterized. Here, the authors analyze age-related proteome and ubiquitylome dynamics in Drosophila and identify increasing H2A ubiquitylation as a conse...

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Autores principales: Lu Yang, Zaijun Ma, Han Wang, Kongyan Niu, Ye Cao, Le Sun, Yang Geng, Bo Yang, Feng Gao, Zuolong Chen, Zhen Wu, Qingqing Li, Yong Shen, Xumin Zhang, Hong Jiang, Yelin Chen, Rui Liu, Nan Liu, Yaoyang Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/f03d59fd69bc4bcba96f8c0cd012a7b5
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spelling oai:doaj.org-article:f03d59fd69bc4bcba96f8c0cd012a7b52021-12-02T15:35:52ZUbiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker10.1038/s41467-019-10136-w2041-1723https://doaj.org/article/f03d59fd69bc4bcba96f8c0cd012a7b52019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10136-whttps://doaj.org/toc/2041-1723Post-translational protein modifications can affect lifespan and aging but age-dependent ubiquitylation changes have not yet been systematically characterized. Here, the authors analyze age-related proteome and ubiquitylome dynamics in Drosophila and identify increasing H2A ubiquitylation as a conserved aging marker.Lu YangZaijun MaHan WangKongyan NiuYe CaoLe SunYang GengBo YangFeng GaoZuolong ChenZhen WuQingqing LiYong ShenXumin ZhangHong JiangYelin ChenRui LiuNan LiuYaoyang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lu Yang
Zaijun Ma
Han Wang
Kongyan Niu
Ye Cao
Le Sun
Yang Geng
Bo Yang
Feng Gao
Zuolong Chen
Zhen Wu
Qingqing Li
Yong Shen
Xumin Zhang
Hong Jiang
Yelin Chen
Rui Liu
Nan Liu
Yaoyang Zhang
Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
description Post-translational protein modifications can affect lifespan and aging but age-dependent ubiquitylation changes have not yet been systematically characterized. Here, the authors analyze age-related proteome and ubiquitylome dynamics in Drosophila and identify increasing H2A ubiquitylation as a conserved aging marker.
format article
author Lu Yang
Zaijun Ma
Han Wang
Kongyan Niu
Ye Cao
Le Sun
Yang Geng
Bo Yang
Feng Gao
Zuolong Chen
Zhen Wu
Qingqing Li
Yong Shen
Xumin Zhang
Hong Jiang
Yelin Chen
Rui Liu
Nan Liu
Yaoyang Zhang
author_facet Lu Yang
Zaijun Ma
Han Wang
Kongyan Niu
Ye Cao
Le Sun
Yang Geng
Bo Yang
Feng Gao
Zuolong Chen
Zhen Wu
Qingqing Li
Yong Shen
Xumin Zhang
Hong Jiang
Yelin Chen
Rui Liu
Nan Liu
Yaoyang Zhang
author_sort Lu Yang
title Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
title_short Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
title_full Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
title_fullStr Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
title_full_unstemmed Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
title_sort ubiquitylome study identifies increased histone 2a ubiquitylation as an evolutionarily conserved aging biomarker
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/f03d59fd69bc4bcba96f8c0cd012a7b5
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