Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways

The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multiple pathways.

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Autores principales:	Sunwoo Oh, Elodie Bournique, Danae Bowen, Pégah Jalili, Ambrocio Sanchez, Ian Ward, Alexandra Dananberg, Lavanya Manjunath, Genevieve P. Tran, Bert L. Semler, John Maciejowski, Marcus Seldin, Rémi Buisson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f03f488fd0c5499ab43ab73627e76395
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spelling	oai:doaj.org-article:f03f488fd0c5499ab43ab73627e763952021-12-02T16:28:01ZGenotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways10.1038/s41467-021-25203-42041-1723https://doaj.org/article/f03f488fd0c5499ab43ab73627e763952021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25203-4https://doaj.org/toc/2041-1723The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multiple pathways.Sunwoo OhElodie BourniqueDanae BowenPégah JaliliAmbrocio SanchezIan WardAlexandra DananbergLavanya ManjunathGenevieve P. TranBert L. SemlerJohn MaciejowskiMarcus SeldinRémi BuissonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sunwoo Oh Elodie Bournique Danae Bowen Pégah Jalili Ambrocio Sanchez Ian Ward Alexandra Dananberg Lavanya Manjunath Genevieve P. Tran Bert L. Semler John Maciejowski Marcus Seldin Rémi Buisson Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways
description	The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multiple pathways.
format	article
author	Sunwoo Oh Elodie Bournique Danae Bowen Pégah Jalili Ambrocio Sanchez Ian Ward Alexandra Dananberg Lavanya Manjunath Genevieve P. Tran Bert L. Semler John Maciejowski Marcus Seldin Rémi Buisson
author_facet	Sunwoo Oh Elodie Bournique Danae Bowen Pégah Jalili Ambrocio Sanchez Ian Ward Alexandra Dananberg Lavanya Manjunath Genevieve P. Tran Bert L. Semler John Maciejowski Marcus Seldin Rémi Buisson
author_sort	Sunwoo Oh
title	Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways
title_short	Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways
title_full	Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways
title_fullStr	Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways
title_full_unstemmed	Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways
title_sort	genotoxic stress and viral infection induce transient expression of apobec3a and pro-inflammatory genes through two distinct pathways
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f03f488fd0c5499ab43ab73627e76395
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Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways

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