Intra-articular use of hyaluronic acid in the treatment of osteoarthritis

Alberto Migliore1,2, Mauro Granata31UOS of Rheumatology S. Pietro Fatebenefratelli Hospital, Rome, Italy; 2AFaR Research Center, S. Pietro, Rome, Italy; 3UOS of Rheumatology S. Filippo Neri Hospital, Rome, ItalyAbstract: Osteoarthritis is one of the leading causes of disability in the elderly. The c...

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Autores principales:	Alberto Migliore, Mauro Granata
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/f045057057cb4f8bb3088482cf05d717
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spelling	oai:doaj.org-article:f045057057cb4f8bb3088482cf05d7172021-12-02T05:56:41ZIntra-articular use of hyaluronic acid in the treatment of osteoarthritis1178-1998https://doaj.org/article/f045057057cb4f8bb3088482cf05d7172008-06-01T00:00:00Zhttps://www.dovepress.com/intra-articular-use-of-hyaluronic-acid-in-the-treatment-of-osteoarthri-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Alberto Migliore1,2, Mauro Granata31UOS of Rheumatology S. Pietro Fatebenefratelli Hospital, Rome, Italy; 2AFaR Research Center, S. Pietro, Rome, Italy; 3UOS of Rheumatology S. Filippo Neri Hospital, Rome, ItalyAbstract: Osteoarthritis is one of the leading causes of disability in the elderly. The changes in the lubricating properties of synovial fluid lead to significant pain and loss of function. More than ten years have passed from the first studies. Up till now many authors have supported intra-articular hyaluronan (HA) therapy as not only a symptom-modifying therapy but also a treatment which may significantly decrease the rate of deterioration of joint structure. In this review we report data relative to knee and hip treatment. The ongoing studies continue to further our understanding of the fundamental mechanisms that likely underlie the therapeutic benefits of this treatment but, despite recent progress, many unresolved issues require further study. Large scale double blind controlled studies must be carried out to confirm these promising data and produce meaningful guidelines.Keywords: osteoarthritis, hyaluronan, intra-articular injections, ultrasound-guided, viscosupplementationAlberto MiglioreMauro GranataDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 365-369 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Alberto Migliore Mauro Granata Intra-articular use of hyaluronic acid in the treatment of osteoarthritis
description	Alberto Migliore1,2, Mauro Granata31UOS of Rheumatology S. Pietro Fatebenefratelli Hospital, Rome, Italy; 2AFaR Research Center, S. Pietro, Rome, Italy; 3UOS of Rheumatology S. Filippo Neri Hospital, Rome, ItalyAbstract: Osteoarthritis is one of the leading causes of disability in the elderly. The changes in the lubricating properties of synovial fluid lead to significant pain and loss of function. More than ten years have passed from the first studies. Up till now many authors have supported intra-articular hyaluronan (HA) therapy as not only a symptom-modifying therapy but also a treatment which may significantly decrease the rate of deterioration of joint structure. In this review we report data relative to knee and hip treatment. The ongoing studies continue to further our understanding of the fundamental mechanisms that likely underlie the therapeutic benefits of this treatment but, despite recent progress, many unresolved issues require further study. Large scale double blind controlled studies must be carried out to confirm these promising data and produce meaningful guidelines.Keywords: osteoarthritis, hyaluronan, intra-articular injections, ultrasound-guided, viscosupplementation
format	article
author	Alberto Migliore Mauro Granata
author_facet	Alberto Migliore Mauro Granata
author_sort	Alberto Migliore
title	Intra-articular use of hyaluronic acid in the treatment of osteoarthritis
title_short	Intra-articular use of hyaluronic acid in the treatment of osteoarthritis
title_full	Intra-articular use of hyaluronic acid in the treatment of osteoarthritis
title_fullStr	Intra-articular use of hyaluronic acid in the treatment of osteoarthritis
title_full_unstemmed	Intra-articular use of hyaluronic acid in the treatment of osteoarthritis
title_sort	intra-articular use of hyaluronic acid in the treatment of osteoarthritis
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/f045057057cb4f8bb3088482cf05d717
work_keys_str_mv	AT albertomigliore intraarticularuseofhyaluronicacidinthetreatmentofosteoarthritis AT maurogranata intraarticularuseofhyaluronicacidinthetreatmentofosteoarthritis
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Intra-articular use of hyaluronic acid in the treatment of osteoarthritis

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