High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis.

<h4>Background</h4>Whether the expression of Golgi phosphoprotein 3 (GOLPH3) correlates with esophageal cancer tumorigenesis is currently unclear. The aim of this study was to examine GOLPH3 expression in patients with esophageal squamous cell cancer (ESCC) and explore its clinical signi...

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Autores principales:	Jian-Hua Wang, Xiu-Ting Chen, Zhe-Sheng Wen, Min Zheng, Jian-Ming Deng, Ming-Zhi Wang, Huan-Xin Lin, Kun Chen, Jun Li, Jing-Ping Yun, Rong-Zhen Luo, Li-Bing Song
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f04c5c3956244a1ea59ea4a30f35c3b1
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spelling	oai:doaj.org-article:f04c5c3956244a1ea59ea4a30f35c3b12021-11-18T08:13:31ZHigh expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis.1932-620310.1371/journal.pone.0045622https://doaj.org/article/f04c5c3956244a1ea59ea4a30f35c3b12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23056210/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Whether the expression of Golgi phosphoprotein 3 (GOLPH3) correlates with esophageal cancer tumorigenesis is currently unclear. The aim of this study was to examine GOLPH3 expression in patients with esophageal squamous cell cancer (ESCC) and explore its clinical significance.<h4>Methods</h4>Differences in the expression of GOLPH3 at the mRNA and protein level were examined via quantitative reverse transcriptase PCR and western blotting, respectively. GOLPH3 expression levels in ESCC tissue were determined through immunohistochemistry, and were compared in accordance with specific clinicopathological features of the patients and tissue specimens. Factors associated with patient survival were also analyzed.<h4>Results</h4>A notably higher level of GOLPH3 expression was found in ESCC cell lines and tissues at both mRNA and protein levels. High expression of GOLPH3 in ESCC patients was positively associated with clinical stage, TNM classification, histological differentiation and vital status (all P<0.0001). Expression of GOLPH3 was found to be an independent prognostic factor in ESCC patients. ESCC patients expressing high levels of GOLPH3 exhibited a substantially lower 5-year overall survival than GOLPH3-negative patients. Furthermore, a significant correlation between high GOLPH3 expression and shorter overall survival time was found in different subgroups of ESCC patients stratified by the clinical stage, T classification, and lymph node metastasis.<h4>Conclusions</h4>Experiments demonstrated potential involvement of GOLPH3 in the development, differentiation, and tumorigenesis of ESCC, and concludes the possibility of its use as a diagnostic and prognostic marker in patients with ESCC.Jian-Hua WangXiu-Ting ChenZhe-Sheng WenMin ZhengJian-Ming DengMing-Zhi WangHuan-Xin LinKun ChenJun LiJing-Ping YunRong-Zhen LuoLi-Bing SongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e45622 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian-Hua Wang Xiu-Ting Chen Zhe-Sheng Wen Min Zheng Jian-Ming Deng Ming-Zhi Wang Huan-Xin Lin Kun Chen Jun Li Jing-Ping Yun Rong-Zhen Luo Li-Bing Song High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis.
description	<h4>Background</h4>Whether the expression of Golgi phosphoprotein 3 (GOLPH3) correlates with esophageal cancer tumorigenesis is currently unclear. The aim of this study was to examine GOLPH3 expression in patients with esophageal squamous cell cancer (ESCC) and explore its clinical significance.<h4>Methods</h4>Differences in the expression of GOLPH3 at the mRNA and protein level were examined via quantitative reverse transcriptase PCR and western blotting, respectively. GOLPH3 expression levels in ESCC tissue were determined through immunohistochemistry, and were compared in accordance with specific clinicopathological features of the patients and tissue specimens. Factors associated with patient survival were also analyzed.<h4>Results</h4>A notably higher level of GOLPH3 expression was found in ESCC cell lines and tissues at both mRNA and protein levels. High expression of GOLPH3 in ESCC patients was positively associated with clinical stage, TNM classification, histological differentiation and vital status (all P<0.0001). Expression of GOLPH3 was found to be an independent prognostic factor in ESCC patients. ESCC patients expressing high levels of GOLPH3 exhibited a substantially lower 5-year overall survival than GOLPH3-negative patients. Furthermore, a significant correlation between high GOLPH3 expression and shorter overall survival time was found in different subgroups of ESCC patients stratified by the clinical stage, T classification, and lymph node metastasis.<h4>Conclusions</h4>Experiments demonstrated potential involvement of GOLPH3 in the development, differentiation, and tumorigenesis of ESCC, and concludes the possibility of its use as a diagnostic and prognostic marker in patients with ESCC.
format	article
author	Jian-Hua Wang Xiu-Ting Chen Zhe-Sheng Wen Min Zheng Jian-Ming Deng Ming-Zhi Wang Huan-Xin Lin Kun Chen Jun Li Jing-Ping Yun Rong-Zhen Luo Li-Bing Song
author_facet	Jian-Hua Wang Xiu-Ting Chen Zhe-Sheng Wen Min Zheng Jian-Ming Deng Ming-Zhi Wang Huan-Xin Lin Kun Chen Jun Li Jing-Ping Yun Rong-Zhen Luo Li-Bing Song
author_sort	Jian-Hua Wang
title	High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis.
title_short	High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis.
title_full	High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis.
title_fullStr	High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis.
title_full_unstemmed	High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis.
title_sort	high expression of golph3 in esophageal squamous cell carcinoma correlates with poor prognosis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/f04c5c3956244a1ea59ea4a30f35c3b1
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_version_	1718422081499037696

High expression of GOLPH3 in esophageal squamous cell carcinoma correlates with poor prognosis.

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