Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome

MazF endoribonucleases are thought to arrest growth of Mycobacterium tuberculosis by global translation inhibition. Here, Barth et al. show that MazF-mt9 cleaves a specific tRNA, leading to ribosome stalling at AAA codons and thus selective mRNA degradation and changes in transcriptome and proteome.

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Auteurs principaux:	Valdir C. Barth, Ju-Mei Zeng, Irina O. Vvedenskaya, Ming Ouyang, Robert N. Husson, Nancy A. Woychik
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f04dbec7370047aab331fe63b011becb
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spelling	oai:doaj.org-article:f04dbec7370047aab331fe63b011becb2021-12-02T16:58:18ZToxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome10.1038/s41467-019-10869-82041-1723https://doaj.org/article/f04dbec7370047aab331fe63b011becb2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10869-8https://doaj.org/toc/2041-1723MazF endoribonucleases are thought to arrest growth of Mycobacterium tuberculosis by global translation inhibition. Here, Barth et al. show that MazF-mt9 cleaves a specific tRNA, leading to ribosome stalling at AAA codons and thus selective mRNA degradation and changes in transcriptome and proteome.Valdir C. BarthJu-Mei ZengIrina O. VvedenskayaMing OuyangRobert N. HussonNancy A. WoychikNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valdir C. Barth Ju-Mei Zeng Irina O. Vvedenskaya Ming Ouyang Robert N. Husson Nancy A. Woychik Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome
description	MazF endoribonucleases are thought to arrest growth of Mycobacterium tuberculosis by global translation inhibition. Here, Barth et al. show that MazF-mt9 cleaves a specific tRNA, leading to ribosome stalling at AAA codons and thus selective mRNA degradation and changes in transcriptome and proteome.
format	article
author	Valdir C. Barth Ju-Mei Zeng Irina O. Vvedenskaya Ming Ouyang Robert N. Husson Nancy A. Woychik
author_facet	Valdir C. Barth Ju-Mei Zeng Irina O. Vvedenskaya Ming Ouyang Robert N. Husson Nancy A. Woychik
author_sort	Valdir C. Barth
title	Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome
title_short	Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome
title_full	Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome
title_fullStr	Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome
title_full_unstemmed	Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome
title_sort	toxin-mediated ribosome stalling reprograms the mycobacterium tuberculosis proteome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f04dbec7370047aab331fe63b011becb
work_keys_str_mv	AT valdircbarth toxinmediatedribosomestallingreprogramsthemycobacteriumtuberculosisproteome AT jumeizeng toxinmediatedribosomestallingreprogramsthemycobacteriumtuberculosisproteome AT irinaovvedenskaya toxinmediatedribosomestallingreprogramsthemycobacteriumtuberculosisproteome AT mingouyang toxinmediatedribosomestallingreprogramsthemycobacteriumtuberculosisproteome AT robertnhusson toxinmediatedribosomestallingreprogramsthemycobacteriumtuberculosisproteome AT nancyawoychik toxinmediatedribosomestallingreprogramsthemycobacteriumtuberculosisproteome
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Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome

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