Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Accumulated HMG-CoA reductase (HMGCR) limits the cholesterol-lowering effect of statins via a feedback loop. Here the authors developed a compound that degrades HMGCR, thus decreasing cholesterol levels and reducing atherosclerotic plaques.

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Detalles Bibliográficos
Autores principales:	Shi-You Jiang, Hui Li, Jing-Jie Tang, Jie Wang, Jie Luo, Bing Liu, Jin-Kai Wang, Xiong-Jie Shi, Hai-Wei Cui, Jie Tang, Fan Yang, Wei Qi, Wen-Wei Qiu, Bao-Liang Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f04e0e5aaf444149a5e2dbbc5d38dc34
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:f04e0e5aaf444149a5e2dbbc5d38dc342021-12-02T14:39:24ZDiscovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol10.1038/s41467-018-07590-32041-1723https://doaj.org/article/f04e0e5aaf444149a5e2dbbc5d38dc342018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07590-3https://doaj.org/toc/2041-1723Accumulated HMG-CoA reductase (HMGCR) limits the cholesterol-lowering effect of statins via a feedback loop. Here the authors developed a compound that degrades HMGCR, thus decreasing cholesterol levels and reducing atherosclerotic plaques.Shi-You JiangHui LiJing-Jie TangJie WangJie LuoBing LiuJin-Kai WangXiong-Jie ShiHai-Wei CuiJie TangFan YangWei QiWen-Wei QiuBao-Liang SongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shi-You Jiang Hui Li Jing-Jie Tang Jie Wang Jie Luo Bing Liu Jin-Kai Wang Xiong-Jie Shi Hai-Wei Cui Jie Tang Fan Yang Wei Qi Wen-Wei Qiu Bao-Liang Song Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
description	Accumulated HMG-CoA reductase (HMGCR) limits the cholesterol-lowering effect of statins via a feedback loop. Here the authors developed a compound that degrades HMGCR, thus decreasing cholesterol levels and reducing atherosclerotic plaques.
format	article
author	Shi-You Jiang Hui Li Jing-Jie Tang Jie Wang Jie Luo Bing Liu Jin-Kai Wang Xiong-Jie Shi Hai-Wei Cui Jie Tang Fan Yang Wei Qi Wen-Wei Qiu Bao-Liang Song
author_facet	Shi-You Jiang Hui Li Jing-Jie Tang Jie Wang Jie Luo Bing Liu Jin-Kai Wang Xiong-Jie Shi Hai-Wei Cui Jie Tang Fan Yang Wei Qi Wen-Wei Qiu Bao-Liang Song
author_sort	Shi-You Jiang
title	Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
title_short	Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
title_full	Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
title_fullStr	Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
title_full_unstemmed	Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
title_sort	discovery of a potent hmg-coa reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f04e0e5aaf444149a5e2dbbc5d38dc34
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Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

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