Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Accumulated HMG-CoA reductase (HMGCR) limits the cholesterol-lowering effect of statins via a feedback loop. Here the authors developed a compound that degrades HMGCR, thus decreasing cholesterol levels and reducing atherosclerotic plaques.

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Detalles Bibliográficos
Autores principales: Shi-You Jiang, Hui Li, Jing-Jie Tang, Jie Wang, Jie Luo, Bing Liu, Jin-Kai Wang, Xiong-Jie Shi, Hai-Wei Cui, Jie Tang, Fan Yang, Wei Qi, Wen-Wei Qiu, Bao-Liang Song
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/f04e0e5aaf444149a5e2dbbc5d38dc34
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